The absorption, metabolism and excretion of disodium cromoglycate in nine animal species

The plasma concentrations and excretion of disodium cromoglycate after iv administration were studied in 9 animal species: mouse, rat, rabbit, dog, silky marmoset, squirrel monkey, Java (cynomolgus) monkey, stump-tailed macaque and baboon. In each species the decline of plasma concentration was rapid and the compound was quickly excreted in the bile and urine. Bile: urine ratios of excreted compound varied, the squirrel monkey excreted most of the dose in the bile (78–88%) whereas the rabbit excreted most of the dose in the urine (74–84%). Other species were intermediate between these two extremes. Tissue residues were low. Poor absorption (1–5%) after oral administration was found. No metabolites were detected in any species.