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A therapeutic exploratory study to determine the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation: CILT |
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| Authors: | Armin D Goralczyk Andreas Schnitzbauer Tung Y Tsui Giuliano Ramadori Thomas Lorf Aiman Obed |
| Affiliation: | (1) Department of General and Visceral Surgery, University Medical Center G?ttingen, G?ttingen, Germany;(2) Klinik und Poliklinik f?r Chirurgie, Universit?tsklinikum Regensburg, Regensburg, Germany;(3) Department of Hepatobiliary and Transplant Surgery, Universit?tsklinikum Hamburg-Eppendorf, Hamburg, Germany;(4) Department of Gastroenterology and Endocrinology, University Medical Center G?ttingen, G?ttingen, Germany |
| Abstract: | BackgroundImmunosuppression with calcineurin inhibitors (CNI) increases the risk of renal dysfunction after orthotopic liver transplantation (OLT). Controlled trials have shown improvement of renal function in patients that received delayed and/or reduced-dose CNI after OLT. Delaying immunosuppression with CNI in combination with induction therapy does not increase the risk of acute rejection but reduces the incidence of acute renal dysfunction. Based on this clinical data this study protocol was designed to assess the efficacy and safety of calcineurin-inhibitor-free de-novo immunosuppression after liver transplantation. |
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