冠心病患者介入治疗后白介素-8和C反应蛋白水平变化的意义

目的：探讨冠心病患者介入治疗后白介素（IL）-8和C反应蛋白（CRP）水平变化。方法：入选2010年3月-2012年12月在本院住院治疗的冠心病患者共90例，根据治疗方法分为 PCI组（70例），保守治疗组（20例），另选择20例健康人群作为健康对照组。比较治疗前，治疗后20d内IL-8和CRP含量的变化。结果：与治疗前比较，治疗后1d PCI组IL-8[（63.22±13.10） pg/ml比（31.58±9.10） pg/ml]、CRP [（14.59±6.13） mg/L比（9.61±2.35） mg/L]水平显著下降，且IL-8明显低于保守治疗组[（50.18±19.31） pg/ml]， P＜0.01；20d后，PCI组IL-8[（15.13±5.22） pg/ml]、CRP [（3.01±0.76） mg/L]水平下降更加显著（P＜0.05-＜0.01），且显著低于保守治疗组[（27.22±14.69） pg/ml ，（5.46±2.77） mg/L]， P均＜0.01，甚至PCI组的IL-8水平与健康对照组[（15.58±4.10） pg/ml]无明显差异（P＞0.05）。结论：PCI术后白介素-8和C反应蛋白水平明显下降，可作为评估冠心病合并动脉粥样硬化患者PCI术后预后的指标。

Meaning of changes of interleukin-8 and C reactive protein levels after PCI in CHD patients

Objective：To explore interleukin （IL）-8 and C reactive protein （CRP） levels change after percutaneous coronary intervention （PCI） in patients with coronary heart disease （CHD） .Methods ：A total of 90 CHD patients , who hospitalized in our hospital from Mar 2010 to Dec 2012 ,were selected .According to their therapeutic methods , they were divided into PCI group （n=70） and conservative treatment group （n=20） .Another 20 healthy people were regarded as healthy control group .Changes of IL-8 and C reactive protein （CRP ） concentrations before and within 20d after treatment were compared among three groups .Results ：Compared with before treatment ,on 1d af-ter treatment ,there were significant reductions in levels of IL-8 [ （63.22 ± 13.10） pg/ml vs .（31.58 ± 9.10） pg/ml] and CRP [ （14.59 ± 6.13） mg/L vs .（9.61 ± 2.35） mg/L] in PCI group ,IL-8 was significantly lower than that of conservative treatment group [（50.18 ± 19.31） pg/ml] ,P〈0.01 ;after 20d ,levels of IL-8 [（15.13 ± 5.22） pg/ml] and CRP [ （3.01 ± 0.76） mg/L] further declined in PCI group （P〈0.05- 〈0.01） ,and they were significantly lower than those of conservative treatment group [ （27.22 ± 14.69） pg/ml ,（5.46 ± 2.77） mg/L] , P〈0.01 all , e-ven the IL-8 level of PCI group was not significant different from that of healthy control group [ （15.58 ± 4.10） pg/ml] , P〉0.05. Conclusion：IL-8 and C reactive protein levels significantly reduce after PCI ,which can be treated as indexes evaluating PCI postoperative prognosis in CHD patients .