阿司匹林并氯吡格雷治疗不稳定型心绞痛198例的疗效

目的：观察阿司匹林联合氯吡格雷治疗不稳定型心绞痛（UAP）的临床疗效。方法：选择我院2010年6月-2013年8月期间收治的396例UAP患者为对象，按照随机数字法均分成联合用药组（常规治疗基础上给予阿司匹林与氯吡格雷联合治疗）和阿司匹林组（在常规治疗基础上仅给予阿司匹林治疗），观察并比较两组患者治疗前后心绞痛发作频率、持续时间的差异和临床治疗效果。结果：和治疗前相比，两组患者治疗后心绞痛发作频率[联合用药组：（4.1±1.2）次/d比（1.8±0.6）次/d，阿司匹林组：（4.0±1.4）次/d比（2.5±3.1）次/d，P＜0.05或＜0.01]和持续时间[联合用药组：（23.2±4.7）min比（3.3±2.6）min，阿司匹林组：（24.9±2.4）min比（7.3±1.6）min]均明显降低，P均＜0.01；但联合用药组患者治疗后心绞痛发作频率和持续时间较阿司匹林组降低更为明显（t＝5.36、6.03，P均＜0.05）；同时联合用药组临床治疗总有效率（98.48％）明显高于阿司匹林组（85.35％），χ2＝22.98，P＝0.002。结论：阿司匹林联合氯吡格雷治疗不稳定型心绞痛患者临床疗效显著，而且安全，值得在临床上应用和推广。

Clinical therapeutic effect of aspirin combined clopidogrel on 198 cases with unstable angina pectoris

Objective：To observe the therapeutic effect of aspirin combined clopidogrel on unstable angina pectoris （UAP） .Methods ：A total of 396 UAP patients hospitalized in our hospital from Jun 2010 to Aug 2013 were en-rolled ,randomly and equally divided into combined medication group （received combined therapy of aspirin and clo-pidogrel based on routine treatment ） and aspirin group （only received aspirin based on routine treatment ） according to number table method .Attack frequency and duration of angina pectoris ,and clinical therapeutic effect were ob-served and compared between two groups before and after treatment .Results：Compared with before treatment , there were significant reductions in attack frequency [combined medication group ：（4.1 ± 1.2） times/d vs .（1.8 ± 0.6） times/d ,aspirin group ：（4.0 ± 1.4） times/d vs .（2.5 ± 3.1） times/d ,P〈0.05 or 〈0.01] and duration of an-gina pectoris [combined medication group ： （23.2 ± 4.7） min vs .（3.3 ± 2.6） min ,aspirin group ： （24.9 ± 2.4） min vs .（7.3 ± 1.6） min , P〈0.01 both] in both groups after treatment ;compared with aspirin group after treat-ment ,there were more significant reductions in attack frequency and duration of angina pectoris in combined medi-cation group （ t = 5.36 ,6.03 respectively , P〈 0.05 both ）;total effective rate of combined medication group （98.48% ） was significantly higher than that of aspirin group （85.35% ） ,χ2 =22.98 , P=0.002 .Conclusion：Com-bined therapy of aspirin and clopidogrel possesses more significant therapeutic effect on patients with unstable angina pectoris , and it is safe ,which worth extending and application in clinic .