血尿酸与冠心病程度及心血管事件的相关性

目的：探讨血尿酸（UA）水平与冠心病（CHD）病变严重程度及与心血管事件的相关性。方法：回顾性分析于我院行冠脉造影403例患者的临床资料，其中308例CHD患者稳定型心绞痛（SAP ，137例）、急性冠脉综合征（ACS ，171例）]，95例非CHD患者（正常对照组），比较各组间UA水平的差异，并进一步分析其与冠脉病变严重程度的相关性。再根据UA水平CHD患者被分为低尿酸组（147例）和高尿酸组（161例），经12个月随访，比较两组随访期间主要不良心血管事件（MACE）的发生率。结果：ACS组血 UA水平显著高于正常对照组（318.44±69.07）μmol/L比（295.38±80.08）μmol/L ，P＝0.003]；随着冠脉病变支数的增加及冠脉病变程度的加重（Gensini评分增高），血UA水平呈显著升高趋势单支（316.58±95.27）μmol/L比双支（335.26±43.26）μmol/L比多支（346.53±86.74）μmol/L ；低分组（312.42±48.26）μmol/L比中分组（346.58±47.36）μmol/L比高分组（363.84±54.68）μmol/L ， P＜0.05或＜0.01]， Pearson相关分析显示，血UA水平与Gensini评分呈正相关（r＝0.583， P＜0.05）；高尿酸组MACE发生率明显高于低尿酸组（58.38％比36.24％， P＝0.012）。结论：血尿酸水平与冠心病严重程度呈正相关，可能为冠心病独立危险因素。

Correlation among serum uric acid level and severity of coronary heart disease,adverse cardiovascular events

Objective：To explore the correlation among serum uric acid （UA） level and severity of coronary heart disease （CHD） ,adverse cardiovascular events .Methods ：Clinical data of 403 patients undergoing coronary angiog-raphy in our hospital were retrospectively analyzed .They were divided into CHD group n=308 ,including 137 cases with stable angina pectoris （SAP） and 171 cases with acute coronary syndrome （ACS）] and normal control group （n=95 ,non-CHD patients） .UA level was compared among all groups and its correlation with CHD severity was fur-ther analyzed .According to UA level ,CHD patients were divided into low UA group （n=147） and high UA group （n=161） ,after 12-month follow-up ,incidence rate of major adverse cardiovascular events （MACE） uring follow-up was compared between two groups .Results：Serum UA level of ACS group was significantly higher than that of nor-mal control group （318.44 ± 69.07）μmol/L vs .（295.38 ± 80.08）μmol/L ,P=0.003];along with number of dis-eased coronary vessels increased and CHD severity aggravated （Gensini score rose ） ,serum UA level showed an in-creasing trend single-branch （316.58 ± 95.27 ） μmol/L vs . double-branch （335.26 ± 43.26 ） μmol/L vs . multi-branch （346.53 ± 86.74） μmol/L ;low score group （312.42 ± 48.26） μmol/L vs .middle score group （346.58 ± 47.36）μmol/L vs .high score group （363.84 ± 54.68）μmol/L , P〈0.05 or 〈0.01] .Pearson correlation analysis indicated that serum UA level was positively correlated with Gensini score （r=0.583 ,P〈0.05）;MACE incidence rate in high UA group was significantly higher than that of low UA group （58.38% vs .36.24% , P=0.012） .Con-clusion：Serum uric acid level is positively correlated with severity of coronary heart disease ,which may be an inde-pendent risk factor for coronary heart disease .