冠心病患者糖化血红蛋白水平与冠脉SYNTAX评分的相关性

目的：探讨冠心病患者糖化血红蛋白水平与冠脉病变严重程度的相关性。方法：选择心内科住院并行冠状动脉造影检查的515例患者资料进行分析，按照冠脉造影结果分为冠心病组（370例）和冠脉造影结果正常组（145例）；冠心病组患者再按糖化血红蛋白水平分为HbA1 c＜7％组（282例）和 HbA1 c≥7％组（88例），按SYNTAX评分分为SYNTAX评分低危组（1-22分，181例）、中危组（23-32分，125例）及高危组（≥33分，64例）三个亚组，分析比较各组间糖化血红蛋白水平的差异。结果：HbA1 c≥7％组冠心病患者的冠脉SYNTAX 评分显著高于HbA1 c＜7％组（25.6±9.97）分比（20.92±10.26）分， P＜0.01]。SYNTAX评分高危组和中危组HbA1c水平显著高于冠脉造影正常组、低危组（8.74±0.83）分、（7.74±0.62）分比（5.12±0.49）分比（5.68±0.59）分]，且低危组也显著高于正常组（P均＜0.01）。Pearson相关分析显示 HbA1c水平与SYNTAX评分呈正相关（r＝0.764，P＜0.01）。结论：糖化血红蛋白水平与冠脉病变严重程度呈正相关，SYNTAX评分高者糖化血红蛋白水平明显高于SYNTAX评分低者。

Correlation between glycosylated hemoglobin level and coronary SYNTAX score in patients with coronary heart disease

Objective：To explore the correlation between glycosylated hemoglobin （HbA1c） level and severity of cor-onary artery disease in patients with coronary heart disease （CHD） .Methods ：Clinical data of 515 patients ,who hospitalized in department of cardiology and received coronary angiography （CAG ） examination ,were analyzed . According to CAG results ,they were divided into CHD group （n=370） and normal CAG group （n=145）;accord-ing to HbA1c level ,CHD patients were further divided into HbA1c〈7% group （n=282） and HbA1c≥7% group （n=88） ,according to SYNTAX score ,they were divided into SYNTAX score low risk group （n=181 ,1-22 scores） , intermediate risk group （n=125 ,23-32 scores） and high risk group （n=64 ,≥33 scores） .HbA1c level was com-pared and analyzed among all groups .Results ：Coronary SYNTAX score of HbA1c≥7% group was significantly higher than that of HbA1c〈7% group （25.6 ± 9.97） scores vs .（20.92 ± 10.26） scores ,P〈0.01] .HbA1c levels in high risk and intermediate risk groups were significantly higher than those of normal CAG group and low risk group （8.74 ± 0.83） scores ,（7.74 ± 0.62） scores vs .（5.12 ± 0.49） scores vs .（5.68 ± 0.59） scores] ,and that of low risk group was significantly higher than that of normal CAG group , P〈0.01 all. Pearson correlation analysis indicated that HbA1c level was positively correlated with coronary SYNTAX score （r=0.764 , P〈0.01） .Conclu-sion：Glycosylated hemoglobin level is positively correlated with severity of coronary artery disease .Its level in those with higher SYNTAX score is significantly higher than that with low SYNTAX score .