国产比伐卢定在急诊介入治疗中对血小板功能的影响

目的：探讨国产比伐卢定在急诊经皮冠状动脉介入治疗（PCI）中对血小板功能的影响。方法：100例急性ST段抬高性心肌梗死接受急诊PCI的患者随机分为肝素组（53例）和比伐卢定组（47例）。检测两组 PCI术前后二磷酸腺苷（ADP）诱导的血小板聚集率，并进行统计学比较。结果：急诊PCI术前，两组 ADP诱导的血小板凝聚率差异无统计学意义（ P＝0.99）。急诊 PCI术后，比伐卢定组 ADP 诱导的血小板凝聚率显著低于肝素组（16.46±10.23）％比（25.21±15.91）％， P＜0.01]。结论：PCI术中，与常规肝素抗凝相比，作为抗凝剂的比伐卢定可以更明显抑制血小板凝聚，具有抗血小板的功能。

Impact of domestic bivalirudin on platelet function during emergency percutaneous coronary intervention

Objective：To explore the impact of domestic bivalirudin on platelet function during emergency percutane-ous coronary intervention （PCI） .Methods ：A total of 100 patients with acute ST segment elevation myocardial in-farction who recieved emergency PCI were randomly divided into unfractionated heparin group （UFH group ,n=53） and bivalirudin group （n=47） .Adenyl diphosphoric acid （ADP）-induced platelet aggregation rate was meas-ured and statistically compared between two groups before and after PCI .Results：Before emergency PCI ,there was no significant difference in ADP-induced platelet aggregation rate between two groups （P=0.99） .After emergency PCI ,ADP-induced platelet aggregation rate in bivalirudin group was significantly lower than that of UFH group （16.46 ± 10.23）% vs .（25.21 ± 15.91） % , P〈0.01] .Conclusion：During percutaneous coronary intervention , compared with routine heparin anticoagulation , bivalirudin , as an anticoagulant , can more significantly inhibit platelet aggregation and possess antiplatelet effect .