The association between periodontitis and interleukin-6 genetic polymorphism -174 G/C: A meta-analysis |
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| Institution: | 1. Polyclinic Department, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, China;2. Department of Stomatology, Central Hospital of China Railway No. 2 Engineering Group, Chengdu, China;1. Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London, United Kingdom;2. Centre for Oral Immunobiology and Regenerative Medicine, Centre for Oral Clinical Research, Institute of Dentistry, Queen Mary University London (QMUL), London, United Kingdom;3. Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, USA;4. Department of Pediatric Dentistry, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA;5. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA;1. Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China;2. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu province, China;1. Post-Graduate Program in Biomedical Sciences, Federal University of Piaui, Parnaiba, Piaui, Brazil;2. Post-Graduate Program in Biotechnology, Federal University of Piaui, Parnaiba, Piaui, Brazil;3. Laboratory of Analysis and Histological Processing (LAPHIS), Federal University of Piaui, Parnaiba, Piaui, Brazil;4. Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, Piaui, Brazil |
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| Abstract: | BackgroundTo evaluate the association between periodontitis and interleukin-6 (IL6) -174 G/C polymorphism by data synthesis and subgroup analysis.MethodsEighteen case-control studies from 16 articles with 1616 cases and 1511 controls were included in this meta-analysis by searching the public databases including PubMed, Embase and Web of Science databases by Jun 2018. Data syntheses were performed using Stata 9.0.ResultsThere were inverse associations of IL6 -174 G/C polymorphism with both general periodontitis and overall periodontitis. In CC vs. GG inheritance model, whose effect was the most profound, the genetic polymorphism reduced the risks of general and overall periodontitis by 60% (95% CI = 0.25-0.65, P < 0.01) and 31% (95% CI = 0.38-0.97, P = 0.04) respectively. In addition, the G/C variation was likely to be protective against moderate (allele C vs. allele G: OR = 0.61, 95% CI = 0.43-0.87, P = 0.01; CC + GC vs. GG: OR = 0.57, 95% CI = 0.37-0.89, P = 0.01) and severe periodontitis (allele C vs. allele G: OR = 0.58, 95% CI = 0.41-0.84, P < 0.01; CC vs. GG: OR = 0.33, 95% CI = 0.13-0.82, P = 0.02) exclusively in Brazilian people. No reliable evidence was found regarding chronic periodontitis.ConclusionThis meta-analysis suggests that IL6 -174 G/C polymorphism may be negatively associated with risk of periodontitis. |
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| Keywords: | Periodontitis Brazilian Caucasian individuals Meta-analysis |
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