Effect of chronic stress on capsaicin-induced dental nociception in a model of pulpitis in rats |
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| Institution: | 1. Endodontology Research Center, Kerman University of Medical Sciences, Kerman, Iran;2. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;3. Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran;4. Oral and Dental Diseases Research Center/Kerman Social Determinants on Oral Health Research Center, Kerman University of Medical Sciences, Kerman, Iran;1. Department of Conservative Dentistry and Periodontology, School of Dentistry, Medical University of Vienna, Vienna, Austria;2. Austrian Cluster for Tissue Regeneration, Vienna, Austria;1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China;2. Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Peking University, Beijing, China;1. Sección de Neurofarmacología y Neurociencias, Instituto de Investigaciones Clínicas “Dr. Américo Negrette”, Facultad de Medicina, Universidad del Zulia, Apartado Postal 23, Maracaibo 4001-A, Venezuela;2. Cátedra de Farmacología, Facultad de Medicina, Universidad del Zulia, Apartado Postal 23, Maracaibo 4001-A, Venezuela;3. Instituto Venezolano de Investigaciones Clínicas (IVIC), Centro de Investigaciones Biomédicas, Laboratorio de Neurobiología, Maracaibo, Venezuela;1. Neuroscience Research Institute, Peking University and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China;2. The Second Affiliated Hospital of Xinxiang Medical University, Henan, China;3. Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Beijing, 100191, China;4. Department of Neurology, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA |
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| Abstract: | ObjectiveChronic stress can alter nociceptive sensitivity. However, the effect of stress exposure on dental nociception has been less addressed. Therefore, the present study investigated the effects of chronic exposures to some social and psychological stresses on pulpal nociceptive responses.DesignThe stress groups were constructed as follows: forced swimming (n = 6), restraint (n = 6), and mild (n = 10) and severe (n = 15) crowding stresses. Rats were subjected to stress for 1 h per day for a week. At the end of the stress session, pulp irritation was induced by intradental application of capsaicin (100 μg). There were another capsaicin or capsaicin plus stress training groups that received articaine 5 min before the administration of capsaicin. Nociceptive responses were recorded for 40 min. The time (in s) of continuous shaking of the lower jaw and excessive grooming and rubbing of the mouth near the procedure site was measured as nociceptive behaviors. Data was analyzed using one-way analysis of variance (ANOVA) followed by post hoc Tukey’s test.ResultsSignificant nociceptive responses were evoked by the administration of capsaicin. Exposures to forced swimming (p < 0.01), restraint (p < 0.001), and both mild and severe crowding stresses (p < 0.05) exaggerated capsaicin-induced nociceptive reaction. There was, however, no significant difference in nociceptive reaction time between the different stress groups. Articaine buccal infiltration attenuated nociceptive time in capsaicin and capsaicin plus stress training groups (p < 0.001).ConclusionsThe current data support the association between chronic stress exposures and nociceptive behavior following intradental capsaicin administration. |
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| Keywords: | Nociceptive behavior Dental Pulpitis Capsaicin Stress Rats |
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