Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
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| Institution: | 1. São Paulo State University (UNESP), School of Dentistry, Department of Pathology and Clinical Propaedeutics, Araçatuba, São Paulo, Brazil;2. School of Dentistry of Campo Grande, Universidade Federal do Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil;3. São Paulo State University (UNESP), School of Natural Sciences and Engineering, Department of Mathematics, Ilha Solteira, São Paulo, Brazil;1. Department of Mycology, Pasteur Institute of Iran, 12, Farvardin street, Tehran 13164, Iran;2. Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Cancer Institute of Tehran, Imam Khomeini Hospital Complex, Tehran, Iran;3. Department of General Surgery, Tehran University of Medical Sciences, Cancer Institute of Tehran, Imam Khomeini Hospital Complex, Tehran, Iran;4. Department of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;1. Institute of Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, China;2. School and Hospital of Stomatology, Cheelo College of Medicine, Shandong University, China;3. Department of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University & Institute of Stomatology, Shandong University, Jinan, China;4. State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China;5. Department of Oncology, Yantai Affiliated Hospital of Binzhou Medicial University, Yantai, China;6. School of Pharmaceutical Sciences, Shandong University, Jinan, China;1. Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan;3. Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 300, Taiwan;4. Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu 300, Taiwan;5. Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan;6. Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua 500, Taiwan;7. Department of Internal Medicine, Division of Endocrinology and Metabolism, Chung Shan Medical University Hospital, Taichung 402, Taiwan;8. School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan;9. Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung 402, Taiwan;10. Biotools, Co., Ltd, New Taipei City 221, Taiwan;11. School of Medicine, College of Medicine, Chang Gung University 333, Taoyuan, Taiwan;12. Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan;13. Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, 333, Taiwan |
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| Abstract: | ObjectiveThis case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients.DesignTwenty-eight dentate patients with head and neck cancer submitted to RT were included in the study. Radiation dose received varied from 4320 to 7020 cGy. Patients with the same demographic and health conditions, but no history of cancer or antineoplastic treatment were used as controls. Clinical examinations were carried out before RT, 15–22 days after starting RT, immediately after and 6 months after RT. Supra and subgingival biofilms were collected and cultivated onto selective and non-selective media. Isolates were identified by biochemical and physiological characteristics. Stimulated and unstimulated salivary flow rate and saliva buffer capacity were also determined.ResultsMucositis, dermatitis, xerostomia, dysgeusia, dysphagia and candidiasis were common after starting RT and during the treatment period. Xerostomia was followed by a decrease in salivary pH and buffer capacity, which showed association with the increase of cariogenic cocci and yeast populations, which were also associated with deterioration of hygiene. Candida and family Enterobacteriaceae showed increased prevalence with RT, and were associated with the occurrence of mucositis and xerostomia.ConclusionsModifications in oral biofilms of irradiated patients showed association with xerostomia and hygiene conditions, which reinforces the necessity of improving patient compliance to oral health care programs. |
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| Keywords: | Oral cancer Head and neck radiotherapy Mucositis Xerostomia Microbiology |
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