| 药效差示血清色谱法研究红花的药效物质基础 |
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| 引用本文： | 乔逸,杨志福,田云,杨静,贾艳艳,文爱东. 药效差示血清色谱法研究红花的药效物质基础[J]. 中国药师, 2010, 13(5): 624-626 |
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| 作者姓名： | 乔逸 杨志福 田云 杨静 贾艳艳 文爱东 |
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| 作者单位： | 第四军医大学西京医院药剂科,西安,710033 |
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| 摘 要： | 目的：应用药效差示血清色谱法探索红花的药效物质基础。方法：采用HPLC指纹图谱分析方法，比较红花提取物及红花阴性提取物最大药效时刻、最小药效时刻的含药血清色谱图，探索红花在正常大鼠体内的药效物质基础。结果：红花提取物中出现了一个与药效强弱有关的物质峰，红花阴性提取物中既无药效也无此物质峰。结论：HSYA是红花的药效物质基础；药效差示血清色谱法是一种研究中药药效物质基础的新方法。
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| 关 键 词： | 红花 药效差示血清色谱 指纹图谱 |
Study on Effective Substance Basis of Carthamus Tinctorrius L by Differential Efficacy of Serum Chromatography |
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| Qiao Yi,Yang Zhifu,Tian Yun,Yang Jing,Jia Yanyan,Wen Aidong. Study on Effective Substance Basis of Carthamus Tinctorrius L by Differential Efficacy of Serum Chromatography[J]. China Pharmacist, 2010, 13(5): 624-626 |
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| Authors: | Qiao Yi Yang Zhifu Tian Yun Yang Jing Jia Yanyan Wen Aidong |
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| Affiliation: | ( Department of Pharmacy, Xingjing Hospital, Fourth Military Medical University, Xi＇an 710033, China) |
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| Abstract: | Objective ： To investigate the effective substance of Carthamus tinctorrius L by differential efficacy of serum chromatography. Method： HPLC fingerprint analytical method was used to investigate the effective substance of Carthamus tinctorrius L in rats, comparing serum containing drug chromatogram of maximum efficacy time with minimum efficacy time between safflower extract and safflower negative extract. Result： A peak has been discovered in safflower extract which was changed with efficacy, safflower negative extract had no efficacy nor the peak of HSYA. Conclusion ： HSYA is the most effective substance of Carthamus tinctorrius L. Differential efficacy of serum chromatography is a new method of studying effective substance of Chinese herbal formula. |
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| Keywords: | Carthamus tinctoriu L Differential Efficacy of Serum Chromatography Finger-print |
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