Anti-Hu antibodies in Merkel cell carcinoma |
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Authors: | Greenlee John E Steffens John D Clawson Susan A Hill Kenneth Dalmau Josep |
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Affiliation: | Neurology Service, Veterans Affairs Medical Center and Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84148, USA. jgreenlee@pol.net |
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Abstract: | Anti-Hu antibody is an antineuronal autoantibody found in a subset of patients with paraneoplastic neurological disease. The antibody was first associated with small cell carcinoma of the lung and is most often used as a marker for this neoplasm in patients presenting with suspected paraneoplastic syndromes. Here we report a patient with a multifaceted neurological disorder in the setting of Merkel cell carcinoma. The patient's serum contained antibodies against the Hu antigen, and the expression of the Hu antigen was demonstrated in the patient's tumor. |
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