十二指肠溃疡病亚型与证型分类的研究

本文检测了活动型十二指肠溃疡病患者的红细胞乙酰胆碱脂酶、血清胃泌素、血清胰多肽、血清皮质醇、餐后胃电及皮肤电等多项生化与电生理指标,结果显示患者上述各指标的均值虽然大多数与正常组均值有差异,但实际上患者与正常对照者各指标的测定值均有程度不等的重叠性.按患者发病因素的不同,初步可以把其分为若干个亚型.说明中医把溃疡病按不同的病因病机分为多个证型的理论是合理的。但研究结果也提示亚型与中医证型并非完全等同,中医证型尚有其自身的病理变化,如肝郁为主型存在试餐后迷走神经功能亢进、餐后胃泌素上升幅度大与胃运动功能亢进的病理生理改变;脾虚为主型存在试餐后胃运动功能减弱的病理生理改变。

Classification of Pathological Sub-type and TCM Syndrome-types of Duodenal Ulcer

This report presents the test results of active duodenal ulcer (ADU) cases, on the subjects of acelylchol ulcer (ACHE), serum PP, gastrin, cortisol, electrogastrogram after test meal and electric potential of skin. The results indicated that there was a difference between patients and healthy persons in mean value of the indexes. But in fact, the value of every index to some extent showed overlap of the two groups in the experiment. According to the different pathogenesis of the disease, it can be classified into several sub-types and the existence of subtypes in ADU suggests that classification of TCM syndrome-type is reasonable. But the results of the experiment also showed that pathological subtypes did not completely equate with TCM syndrome-types. The TCM syndrome-types manifested their own pathological changes, for instance, the patients with stagnation of liver-qi had the vagal hyperfunction, hypersecretion of gastrin and hyperanacinesia of the stomach after test meal; the patients with spleen-asthenia had decrement of gastric motion after test meal.