Isolation and radiation hybrid mapping of dinucleotide repeat polymorphism at the human matrix Gla protein (MGP) locus |
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| Authors: | Ikuyo Watanabe Kazuhiro Tsukamoto Tadayoshi Shiba M. Emi |
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| Affiliation: | (1) Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211, Japan Tel. +81-44-733-5230; Fax +81-44-733-5192 e-mail: memi@nms.ac.jp, JP;(2) Department of Molecular Biology, Faculty of Science, Kitazato University, Sagamihara, Japan, JP |
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| Abstract: | Matrix Gla protein (MGP) is an 84-residue, vitamin K-dependent protein expressed by chondrocytes and vascular smooth muscle cells, and is a potent regulator of calcium deposition in cartilage and arterial wall. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human MGP gene. This polymorphism will be useful in genetic studies of arteriosclerosis and osteoporosis. Received: November 5, 1997 / Accepted November 27, 1997 |
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| Keywords: | Matrix Gla protein Polymorphism dinucleotide repeat Arteriosclerosis Osteoporosis |
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