脑梗死病人平均血小板体积的改变及临床意义

目的 :探讨脑梗死 (CI)病人平均血小板体积 (MPV )的改变及临床意义。方法 :测定 12 7例CI病人急性发作期以及恢复期MPV、血小板计数 (PLT )、血小板体积分布宽度 (PDW )。 80例健康体检者作为对照。结果 :CI病人急性期较恢复期及对照组MPV、PDW明显升高 ,PLT显著下降 (P <0 .0 1)。CI病人不同梗死面积组之间MPV差异显著 ,梗死面积越大 ,MPV越大。结论 :MPV与CI密切相关 ,并且是CI的一个独立的危险因素。动态监测CI病人的MPV ,一方面有助于病人病情轻重程度的判定 ,一方面可以了解CI病人血小板的活化情况 ,及时调节抗血小板治疗 ,以便改善脑梗死的预后。

The Changes of Mean Platelet Volume and Its Clinical Significance in Patients with Cerebral Infarction

Objective:To investigate the changes of mean platelet volume(MPV) and its clinical significance in patients with cerebral infarction(CI). Methods:The MPV, PLT, PDW were detected in 80 health persons and 127 CI patients in dangerous and steady period. Results:The MPV and PDW of CI patients in dangerous period were higher than in steady period and health persons, however PLT were reduced(P<0.05).The MPV in three groups with different infarction area was different significantly each other(P<0.05). The infarction area was greater, the MPV was higher. Conclusion:MPV has a close relationship with CI and may be a dependent dangerous factor of CI. It will help to evaluate the severe extent of CI and give a anti-platelet treatment as soon as possible to improve the prognosis of CI through monitoring the MPV of CI patients successively.