| 维生素A和铁缺乏对大鼠红系造血影响的比较 |
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| 引用本文： | 李廷玉,瞿平,刘友学,王亚平,黎海芪,郑惠连. 维生素A和铁缺乏对大鼠红系造血影响的比较[J]. 中国儿童保健杂志, 1995, 0(2) |
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| 作者姓名： | 李廷玉 瞿平 刘友学 王亚平 黎海芪 郑惠连 |
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| 作者单位： | 重庆医科大学儿童医院，重庆医科大学儿童医院，重庆医科大学儿童医院，重庆医科大学组胚教研室，重庆医科大学儿童医院，重庆医科大学儿童医院 630014，630014，630014，630014，630014 |
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| 基金项目： | 国家自然科学基金资助课题 |
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| 摘 要： | 采用体外培养红系祖细胞(BFU-E、CFU-E),观察维生素A缺乏(VAD),或铁缺乏(ID)对断乳期大鼠红系造血的影响,结果发现VAD和ID大鼠的BFU-E及CFU-E集落数明显低于正常组,ID组的BFU-E及CFU-E集落数及每一集落的细胞数均明显低于正常及VAD组;补充VA和铁剂后BFU-E及CFU-E集落数明显增加,提示VAD和ID可能通过不同机制引起骨髓红系祖细胞增殖分化抑制。
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| 关 键 词： | 维生素A缺乏 铁缺乏 早期红系祖细胞 晚期红系祖细胞 大鼠 |
COMPARATIVE ERYTHROPOIESIS IN VITAMIN A AND IRON DEFICIENT RATS |
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| Li Tingyu,et al. COMPARATIVE ERYTHROPOIESIS IN VITAMIN A AND IRON DEFICIENT RATS[J]. Chinese Journal of Child Health Care, 1995, 0(2) |
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| Authors: | Li Tingyu et al |
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| Abstract: | To study effects of vitamin A(VA)and iron deficiency on erythropoiesis in weaning rats, the growth of erythroid burstforming unit (BFU-E) and erythroid colony-forming unit (CFU-E)in vitro were observed. The results were found that the growth BFU-E and CFU-E in VA or iron deficient rats were decreased compared with control group. The growth of BFU-E and CFU-E, number of cells per colony in iron deficient group were decreased compared with control and VA deficient groups. Resupplementation by VA or iron produced positive growth of BFU-E and CFU-E in vitro. The data suggest that the proliferation and differentiation of erythroid progenitors were impaired in VA or iron deficient rats by respective mechanism. |
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| Keywords: | vitamin A Iron deficiency BFU-E CFU-E Rat. |
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