静滴复方丹参注射液对腰椎间盘突出症患者自由基代谢的影响

目的　观察复方丹参注射液静滴对腰椎间盘突出症 (LIDP)患者血清一氧化氮 (NO)和超氧化物歧化酶 (SOD)的影响及其疗效。方法　将 4 2例LIDP患者随机分为丹参组 2 1例和常规组 2 1例进行比较 ,于治疗前、后分别用硝酸还原酶法和羟胺氧化法测定患者血清NO含量及SOD活性 ,同时应用目测类比评分法 (VAS)对疼痛进行评估 ,采用LIDP疗效定量评价进行疗效评定。结果　LIDP患者复方丹参液静滴治疗后 ,血浆NO含量减少和SOD活性增高 ,与常规组相比差异有显著意义 (P <0 0 5 ) ;丹参组疗效优于常规组。结论　复方丹参注射液静滴可降低LIDP患者NO水平 ,提高SOD活性 ,增强机体抗氧能力 ,减轻自由基的损害 ,临床疗效优于常规组

Effects of intravenous drip of compound Danshen injection on plasma NO and SOD levels in patients with lumbar intervertebral disc prolapse

Objective To observe the effects of intravenous drip of compound Danshen injection on plasma nitric oxide(NO) and superoxide dismutase(SOD) levels in patients with lumbar intervertebral disc prolapse(LIDP) and the therapeutic effect.Methods 42 cases of LIDP were randomly divided into compound Danshen injection intravenous drip treatment group(Danshen group,n=21) and routine treatment group(routine group,n=21).The level of plasma NO and SOD were measured before treatment and 2 weeks after treatment.The assessment included visual analogue scale(VAS) for pain grading and LIDP quantitative evaluation scale for therapeutic effects at the same time.Results The SOD of the patients in the two groups increased after treatment and the level of NO decreased(P<0.05).Compared with the routine group,the levels of plasma NO decreased significantly in the compound Danshen injection group,and the activities of SOD was significantly higher(P<0.05) than routine group.The effect of compound Danshen injection group was better than that of routine group in the treatment of LIDP.Conclusion Compound Danshen injection can decrease the level of NO and increase the level of SOD of the patients with LIDP and increase the antioxidization capacity to alleviate the damage by oxygen free radicals,and yield better therapeutic result than of routine lntevention for patients with LIDP.