强制性脓毒症治疗流程对严重脓毒症和脓毒性休克预后影响

目的 研究强制性脓毒症治疗流程对严重脓毒症和脓毒性休克患者预后的影响.方法 前瞻性研究2008年6月至2009年12月就诊于两个三级教学医院急诊科的严重脓毒症及脓毒性休克患者195例;应用拯救脓毒症运动标准数据库(SSC database)研究脓毒症患者临床的特点、治疗和预后.纳人标准:符合SSC database诊断标准.2008年6月至12月就诊患者进行现况调查,依据临床医师经验治疗,为对照组.2009年1月至12月间就诊患者采用强制性脓毒症治疗流程治疗,即治疗组.比较强制性脓毒症治疗流程实施前后两组住院病死率.采用SPSS 15.0软件进行数据分析.组间比较采用独立样本t检验.计数资料以率和构成比表示,采用χ2检验.用Kaplan-Meier进行生存曲线分析,以P＜0.05为差异具有统计学意义.结果 治疗组[98.3%(115/117)]与对照组[2.56%(2/78)]比较显著提高血乳酸的检测率(P＜0.01);治疗组69.2%(81/117)患者可以在来诊3 h内给予抗生素,对照组为35.8%(28/78)(P＜0.01);治疗组[47.9%(56/117)]与对照组[25.6%(20/78)]比较显著增加抗生素应用前血培养送检率(P=0.003);治疗组[80.3%(53/66)]与对照组[27%(10/37)]比较显著增加标准液体复苏率,P＜0.01;治疗组[8.1%(3/37)]与对照组[27.3%(18/66)]比较中心静脉压达标率增加(P=0.023);治疗组[29.1%(34/117)]与对照组[44.8%(35/78)]比较住院病死率显著下降(P=0.032).结论 强制性实施脓毒症治疗流程提高了严重脓毒症和脓毒性休克标准治疗依从性,住院病死率下降15.7%.

Abstract：

Objective To study the impact of therapy strategy on outcomes of patients suffering from severe sepsis and/or septic shock. Method A total of 195 patients diagnosed as severe sepsis or septic shock were enrolled for prospective study from June 2008 to December 2009. Patient's clinical manifestation,treatments and outcomes were studied by using SSC database. Patients were divided into control group and treatment group. In control group, patients enrolled from June 2008 to December 2008, were treated with conventional medical care In treatment group, patients enrolled from January 2009 to December 2009 were treated with a novel algorithm of mandatory treatment for sepsis In-hospital mortality of two groups was compared. SPSS15.0 software was used for analysis of data. Chi-square test and unpaired t-test were used for comparisons between groups. Results Compared to the control group The need for blood lactate test was significantly grown in treatment group [98.2% (115/117) versus 2.56% (2/78), P ＜ 0.001]. Antibiotics was administered to 69.2% (81/117) patients of treatment group within 3 hours after their arrival at the emergency department compared to 35.8% (28/78) in the control group (P ＜ 0. 001). Blood cultures made before antibiotics given were 47.9% (56/117) in the treatment group compared to the control group 25.6%(20/78), P = 0. 003. The rate of fluid resuscitation was 80.3% (53/66) in the treatment group and 27%(10/37) in the control group, P ＜0.001. The rate of CVP (8 mmHg was 27.3% (18/66) in the treatment group and 8.1% (3/37) in the control group, P = 0. 023. In-hospital mortality was 29.1% (34/117) in the treatment group and 44.8% (35/78) in the control group, P =0. 032. Conclusions The algorithm of mandatory treatment for sepsis improved the therapeutic efficacy of the treatment for severe sepsis and septic shock, decreasing in-hospital mortality.

The impact of an algorithm of mandatory treatment of sepsis on the outcomes of patients suffering from severe sepsis and septic shock

Objective To study the impact of therapy strategy on outcomes of patients suffering from severe sepsis and/or septic shock. Method A total of 195 patients diagnosed as severe sepsis or septic shock were enrolled for prospective study from June 2008 to December 2009. Patient's clinical manifestation,treatments and outcomes were studied by using SSC database. Patients were divided into control group and treatment group. In control group, patients enrolled from June 2008 to December 2008, were treated with conventional medical care In treatment group, patients enrolled from January 2009 to December 2009 were treated with a novel algorithm of mandatory treatment for sepsis In-hospital mortality of two groups was compared. SPSS15.0 software was used for analysis of data. Chi-square test and unpaired t-test were used for comparisons between groups. Results Compared to the control group The need for blood lactate test was significantly grown in treatment group [98.2% (115/117) versus 2.56% (2/78), P ＜ 0.001]. Antibiotics was administered to 69.2% (81/117) patients of treatment group within 3 hours after their arrival at the emergency department compared to 35.8% (28/78) in the control group (P ＜ 0. 001). Blood cultures made before antibiotics given were 47.9% (56/117) in the treatment group compared to the control group 25.6%(20/78), P = 0. 003. The rate of fluid resuscitation was 80.3% (53/66) in the treatment group and 27%(10/37) in the control group, P ＜0.001. The rate of CVP (8 mmHg was 27.3% (18/66) in the treatment group and 8.1% (3/37) in the control group, P = 0. 023. In-hospital mortality was 29.1% (34/117) in the treatment group and 44.8% (35/78) in the control group, P =0. 032. Conclusions The algorithm of mandatory treatment for sepsis improved the therapeutic efficacy of the treatment for severe sepsis and septic shock, decreasing in-hospital mortality.