| 帕金森病模型大鼠内侧前额叶皮质5-HT_3受体表达的变化 |
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| 引用本文： | 席悦,李文娟,张巧俊,袁海峰,郭方圆,张李娜,张欢.帕金森病模型大鼠内侧前额叶皮质5-HT_3受体表达的变化[J].陕西医学杂志,2013,42(4):387-390. |
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| 作者姓名： | 席悦 李文娟 张巧俊 袁海峰 郭方圆 张李娜 张欢 |
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| 作者单位： | 西安交通大学医学院第二附属医院脑病科,西安,710004 |
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| 基金项目： | 国家自然科学基金项目资助，陕西省科技攻关项目资助 |
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| 摘 要： | 目的:观察帕金森病(PD)模型大鼠内侧前额叶皮质(mPFC)5-羟色胺3(5-HT3)受体表达的变化,探讨其在PD非运动症状产生过程中所发挥的作用。方法:采用免疫组织化学方法,观察5-HT3受体在PD模型大鼠mPFC及其各个分区内的表达变化,并与健康对照组进行比较。结果:与对照组相比,PD大鼠损毁侧mPFC及其中央前区中部(PrCm)、前扣带回(ACd)、前边缘区(PL)、下边缘区(IL)四个分区内5-HT3受体阳性细胞明显稀疏(P<0.05)。结论:PD状态下mPFC及其各个分区内5-HT3受体表达下调。
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| 关 键 词： | 帕金森病 受体 血清素 动物 实验 大鼠 |
The altered expression of 5-HT3 receptor in medial prefrontal cortex of rat with parkinson's disease |
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| Institution: | Department of Encephalopathy,the Second Affiliated Hospital,Medical School of Xi’an Jiaotong University(Xi’an 710004) Xi Yue Li Wenjuan Zhang Qiaojun et al |
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| Abstract: | Objectives: To investigate the altered expression of 5-HT3 receptor in medial prefrontal cortex(mPFC)of Parkinson's disease(PD)model rat and explore the role of 5-HT3 receptor in the pathogenesy of non-motor symptoms in PD.Methods: The altered expression of 5-HT3 receptor in mPFC and its subregions of PD rats was analysed by immunocytochemical SP technique,then it was compared to the normal rats.Results: The counting of 5-HT3 receptor positive cells in mPFC and its subregions(PrCm、ACd、PL、IL) of PD rats showed a significant decrease when compared to the normal rats,respectively(P<0.05).Conclusion: The result suggest that 5-HT3 receptor dysfunction in the mPFC and its subregions of PD. |
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| Keywords: | Parkinson disease Receptors serotonin Animals laboratory Rats |
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