首发精神分裂症患者治疗前后血浆白细胞介素-2等指标的变化

目的　观察首发精神分裂症患者治疗前后血浆白细胞介素 - 2 (IL - 2 )、可溶性白细胞介素 - 2受体 (sIL -2R)、白细胞介素 - 6 (IL - 6 )及可溶性白细胞介素 - 6受体 (sIL - 6R)水平变化。方法　选取符合中国精神疾病诊断标准及分类方案第三版 (CCMD - 3)首发精神分裂症住院病人 30例为观察组 ,(病例组 )PANSS量表评分≥ 6 0分 ;选取正常对照组 2 8例。采用酶联免疫吸附法 (ELISA)测定对照组和观察组治疗前及治疗后 6周症状基本缓解后血浆IL - 2、sIL - 2R、IL - 6及sIL - 6R的浓度并进行组间比较。结果　与对照组相比 ,病例组治疗前血清IL - 2、sIL - 2R、IL - 6及sIL - 6R水平显著升高 (P <0 0 5 ) ,治疗后sIL - 2R及IL - 6水平仍有显著升高 (P <0 0 5 ) ,而IL - 2及sIL - 6R水平差异无显著性 (P >0 ,0 5 ) ;病例组治疗前后相比 ,血清IL - 2及sIL - 6R水平显著下降 ,IL - 6水平显著升高 (P <0 0 5 ) ,sIL - 2R治疗前后差异无显著性 (P >0 0 5 )。结论　精神分裂症患者存在免疫功能紊乱 ,抗精神病药物治疗后IL - 2、IL - 6及sIL - 6R发生变化。

Changes in Plasma Levels of Interleukin-2 in First-Episode Schizophrenics before and after Treatment

Objective To evaluate the changes in plasma levels of interleukin-2(IL-2),soluble interlekin-2 receptor (sIL-2 R),interleukin-6(IL-6) and soluble interleukin-6 receptor (sIL-6 R) in first-episode schizophrenics before and after treatment.Methods Thirty inpatients selected with CCMD-3 creteria for first-episode schizophrenia (the PANSS scores less than 60) were enrolled into case group,and twenty-eight healthy volunteers into control group.The levels of IL2,sIL-2 R,IL-6,and sIL-6 R were measured with enzyme-linked immunosorbent assey (ELISA) for both control group and case group before and after treatment for 6 weeks,and comparisions were made between the two groups.Results Compared with the control group,the plasma levels of IL-2,sIL-2 R,IL-6,sIL-6 R in the case group increased significantly before treatment (P<0.05),the level of sIL-2 R and IL-6 in case group also increased significantly after treatment (P<0.05),but the levels of IL-2 and sIL-6 R in case group had no significant difference after treatment.Compared with the case group before treatment,the level of IL-2 and sIL-6 R decreased significantly after treatment (P<0.05).However,the levele of IL-6 increased significantly (P<0.05),meanwhile the level of sIL-2 R had no evident difference.Conclusions Schizophrenics have immune dysfunction,and the levels in IL-2,IL-6,and sIL-6 R change before and after treatment.