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| 国产沉香中的倍半萜类和单萜类化学成分 | |
| 引用本文： | 杨林,乔立瑞,谢丹,戴均贵,郭顺星. 国产沉香中的倍半萜类和单萜类化学成分[J]. 中国中药杂志, 2012, 37(13): 1973-1976 |
| 作者姓名： | 杨林 乔立瑞 谢丹 戴均贵 郭顺星 |
| 作者单位： | 1. 中国医学科学院北京协和医学院药用植物研究所,北京100193;中国医学科学院北京协和医学院药物研究所,北京100050;中央民族大学生命与环境科学学院,北京100081 2. 中国医学科学院北京协和医学院药物研究所,北京,100050 3. 中国医学科学院北京协和医学院药用植物研究所,北京,100193 |
| 基金项目： | 国家"重大新药创制"科技重大专项(2009ZX09301-03-03),国际科技合作项目(2009DFA32250);国家民委科研项目(09ZY0142) |
| 摘 要： | 目的:研究国产沉香的化学成分.方法:通过多种色谱手段,对国产沉香的石油醚及乙醇提取物进行化学成分分离,采用现代波谱技术对化合物的结构进行鉴定.结果:从国产沉香中分离得到9个化合物,分别鉴定为3,3,7-trimethyltri-cycloundecan-8-one(1),longifolene(2),norlongilactone(3),caryophyllenol-Ⅱ(4),humulene diepoxide A(5),kobusone(6),(一)-bornyl ferulate (7),(24R)-24-ethylecholesta-4,22-dien-3-one (8),(24R)-24-3-ono-4-en-sitosterone (9).结论:化合物2～9均为首次从国产沉香中分离得到的化合物.化合物1～6为倍半萜类化合物,化合物7为单萜衍生物,化合物8,9为甾类衍生物. |
| 关 键 词： | 国产沉香 倍半萜类 单萜类 甾体类 |
| 收稿时间： | 2011-11-23 |
Sesquiterpenes and monoterpene from Aquilaria sinensis |
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| YANG Lin,QIAO Lirui,XIE Dan,DAI Jungui and GUO Shunxing. Sesquiterpenes and monoterpene from Aquilaria sinensis[J]. China Journal of Chinese Materia Medica, 2012, 37(13): 1973-1976 | |
| Authors: | YANG Lin QIAO Lirui XIE Dan DAI Jungui GUO Shunxing |
| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China |
| Abstract: | The column chromatography on silica gel,semi-preparative HPLC were used to separate and purify the compounds from the petroleum ether and ethanol extract of Aquilaria sinensis.Nine compounds were isolated.On the basis of their spectroscopic data,the structures were identified as 3,3,7-trimethyltricycloundecan-8-one(1),longifolene(2),norlongilactone(3),caryophyllenol-II(4),humulene diepoxide A(5),kobusone(6),(-)-bornyl ferulate(7),(24R)-24-ethylcholesta-4,22-dien-3-one(8),(24R)-24-3-ono-4-en-sitosterone(9).Compounds 2-9 were isolated from this plant for the first time.compounds 1-6 are sesquiterpenes,compound 7 is a monoterpene derivative,compound 8 and 9 are steroids. |
| Keywords: | Aquilaria sinensis sesquiterpenes monoterpene steroids |
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