| 黄酮类金属配合物的生物活性研究进展 |
| |
| 引用本文： | 刘衍季,何小燕,左华,张齐雄,李逐波,施伦勇. 黄酮类金属配合物的生物活性研究进展[J]. 中国中药杂志, 2012, 37(13): 1901-1904 |
| |
| 作者姓名： | 刘衍季 何小燕 左华 张齐雄 李逐波 施伦勇 |
| |
| 作者单位： | 西南大学药学院,重庆,400716 |
| |
| 基金项目： | 重庆市科技攻关项目(CSTC,2008AA1001) |
| |
| 摘 要： | 中药的黄酮类成分与金属离子形成配合物后,其抗菌、抗病毒、抗炎、抗肿瘤、降血糖、抗溃疡和抗自由基等生物活性会显著增强,原因可能是配合物形成后结构发生改变而使其更易接近靶点产生更强的结合力,或是发挥黄酮类中药活性成分与金属离子的协同作用.该文就黄酮类金属配合物的生物活性及其作用机制研究进行综述,旨在为黄酮类中药有效成分的深入研究及开发提供参考.
|
| 关 键 词： | 黄酮类 配合物 生物活性 作用机制 |
| 收稿时间： | 2011-09-24 |
Advance of studies on bioactivity of flavonoid-metal complexes |
| |
| LIU Yanji,HE Xiaoyan,ZUO Hu,ZHANG Qixiong,LI Zhubo and SHI Lunyong. Advance of studies on bioactivity of flavonoid-metal complexes[J]. China Journal of Chinese Materia Medica, 2012, 37(13): 1901-1904 |
| |
| Authors: | LIU Yanji HE Xiaoyan ZUO Hu ZHANG Qixiong LI Zhubo SHI Lunyong |
| |
| Affiliation: | College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China |
| |
| Abstract: | The flavonoid-metal complexes showed obviously stronger bioactivities such as antibiosis, antivirus, anti-inflammatory, anti-tumor and anti-free-radical, possibly because of the stronger binding force caused by the change in complex structure and accessibility to target spots, or the synergy effect between flavonoids and metallic ions. This essay summarizes studies on bioactivity and mechanism of flavonoid-metal complexes, in order to provide reference for in-depth study and development on effective constituents contained in flavonoid traditional Chinese medicines. |
| |
| Keywords: | flavonoid flavonoid-metal complex bioactivity mechanism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
