| 替比夫定与阿德福韦酯治疗慢性乙型肝炎的临床疗效比较 |
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| 引用本文： | 侯玉香,雷兴琼,钱振育,岑晓红,夏洪涛.替比夫定与阿德福韦酯治疗慢性乙型肝炎的临床疗效比较[J].胃肠病学和肝病学杂志,2010,19(1). |
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| 作者姓名： | 侯玉香 雷兴琼 钱振育 岑晓红 夏洪涛 |
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| 作者单位： | 广东省东莞市康华医院消化科,广东,东莞,523080 |
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| 摘 要： | 目的 比较替比夫定与阿德福韦酯治疗慢性乙型肝炎(CHB)48周的临床疗效和安全性.方法 选取2008年1月～2008年12月门诊44例CHB患者,应用替比夫定治疗,600 mg,1次/d,口服.同期30例CHB患者应用阿德福韦酯治疗,10 mg,1次/d,口服.均服用48周.观察48周血清丙氨酸转氨酶复常率、乙型肝炎病毒(HBV-DNA)阴转率、HBeAg阴转率和HBeAg血清转换率.并分别观察两组在12周、24周、36周的HBV-DNA阴转率、HBeAg阴转率.结果 48周替比夫定ALT复常率95.5%(42/44),HBV-DNA阴转率54.5%(24/44),HBeAg阴转率为27.3%(12/44),HBeAg血清转换率11.4%(5/44),阿德福韦酯分别为93.3%(28/30)、26.7%(8/30)、3.3%(1/30),未发生HBeAg血清学转换.替比夫定HBV-DNA在24周阴转率为47.7%(21/44),HBeAg在24周阴转率为25%(11/44),阿德福韦酯在24周HBV-DNA阴转率为13.3%(4/30),24周未发生HBeAg阴转.结论 替比夫定较阿德福韦酯有更快速、强效抗病毒作用,具有较高HBeAg阴转率和HBeAg血清转换率.
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| 关 键 词： | 慢性乙型肝炎 替比夫定 阿德福韦酯 丙氨酸转氨酶 |
Comparing study on telbivudine and adefovir dipivoxil for the treatment of chronic Hepatitis B |
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| HOU Yuxiang,LEI Xingqiong,QIAN Zhenyu,CEN Xiaohong,XIA Hongtao.Comparing study on telbivudine and adefovir dipivoxil for the treatment of chronic Hepatitis B[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(1). |
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| Authors: | HOU Yuxiang LEI Xingqiong QIAN Zhenyu CEN Xiaohong XIA Hongtao |
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| Institution: | HOU Yuxiang,LEI Xingqiong,QIAN Zhenyu,CEN Xiaohong,XIA Hongtao Department of Gastroenterology,Dongguan Kanghua Hospital of Guangdong Province,Dongguan 523080,China |
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| Abstract: | Objective To compare the clinical efficacy and safety of telbivudine and adefovir dipivoxil on chronic hepatitis B for 48 weeks.Methods Forty-four patients were treated with telbivudine(600 mg qd) and thirty patients were treated with adefovir dipivoxil(10 mg qd) for 48 weeks.After 48 weeks treatment,the normalization rate of ALT levels,the negative conversion rate of HBV-DNA,the negative conversion rates of HBeAg and the seroconversion rate of HBeAg were observed.The negative conversion rates of HBV-DNA an... |
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| Keywords: | Chronic hepatitis B Telbivudine Adefovir dipivoxil Alanine aminotransferase |
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