血清白细胞水平与急性缺血性卒中患者病情及预后的关系

目的:探讨急性缺血性卒中患者血清白细胞水平与其病情及预后的关系。方法:370例急性缺血性卒中患者于入院24 h内测定血清白细胞计数,分为白细胞正常组(I组)及白细胞异常组(Ⅱ组),并于入院后24～48 h内行头颅CT或MRI检查明确为急性脑梗死。入院时、治疗后14 d以NI HSS量表评定神经功能缺损程度,BI量表评定日常生活能力,治疗后90 d随访所有患者的改良Rankin评分(mRS)。结果:入院及治疗14 d时,Ⅱ组NI HSS评分明显高于I组(P<0.05～0.01),BI评分明显低于Ⅰ组(P<0.05～0.01);治疗后14 dⅠ组NI HSS评分降低趋势明显优于Ⅱ组,治疗后90 dⅠ组mRS良好预后的患者比例显著高于Ⅱ组(P<0.01)。结论:缺血性卒中患者血清白细胞水平与其病情及预后有明显相关性,可用于病情及预后的评估。

Relationship between poststroke serum WBC level and the severity and prognosis of ischemic stroke

Objective： To discuss the relationship between poststroke serum WBC level and the severity and prognosis of ischemic stroke.Methods： A total of 370 acute ischemic stroke patients whose serum WBC level was measured within 24 hrs after admission were included in this study.Then patients were divided into two groups： normal level serum WBC group（group I） and high level serum WBC group（group Ⅱ）.All the patients were examined with cerebral CT or MRI scanning within 24-48 hrs after admission and respectively estimated by NIHSS score based on deficit in their clinical neurological function,by BI score to determine the capacity of routine life immediately and 14 d after their admission.And all the patients were estimated mended Rankin score after 90 days′ following-up.Results： The NIHSS scores were significantly lower in group I than that of in group Ⅱ both immediately and 14-day after admission（P0.05）.While the BI scores in group I were very significantly higher than that of in group Ⅱ（P0.01）.After 90 days′ treatment,the mRS fine prognosis ratio in group Ⅰ was significantly higher than that of group Ⅱ（P0.01）.Conclusion： There is a significant positive relationship between serum WBC level and the severity and prognosis of acute ischemic stroke.These findings are consistent with the hypothesis that serum WBC level could be a good marker for estimating the severity and prognosis of acute ischemic stroke.