药物维持治疗联合家庭干预对首发精神分裂症患者的影响

目的:探讨药物维持治疗联合家庭干预对缓解期首发精神分裂症患者的影响。方法:选择经过急性期治疗后病情稳定的精神分裂症患者60例,将其随机等分为家庭干预组和对照组,对照组予以单纯药物维持治疗,家庭干预组予以药物维持治疗和家庭干预。采用社会支持量表(SSRS)、简明精神病量表(BPRS)及自知力与治疗态度问卷(ITAQ)分别于患者入组时和治疗1年后采用盲法评定两组患者的精神病性症状严重程度、自知力和社会支持情况。结果:1年后家庭干预组患者再住院率、BPRS评分低于对照组(P0.05),主观支持、支持利用度、ITAQ评分高于对照组(P0.05),两组客观支持评分差异无统计学意义(P0.05)。结论:与单纯的药物维持治疗相比,药物维持治疗联合家庭干预可以有效地降低患者1年内的再住院率,更好地维持患者病情稳定,促进自知力的恢复,提高主观支持和支持利用度。

The effect of drug maintenance therapy combined with family intervention for the first- episode schizophrenia in stable condition

Objective： To discuss the effect of drug maintenance therapy combined with family intervention with simple drug maintenance therapy for the first-episode schizophrenia in stable condition. Methods： After the treatment of acute phase,60 patients in stable condition met the study criteria were selected to be divided into intervention group and control group at ranadom. The family intervention group received drug maintenance therapy and family intervention and the control group received simple drug maintenance therapy. The patients of two groups were assessed blindly by Social Support Scale（ SSRS）,Brief Psychiatric Rating Scale（ BPRS） and Insight and Treatment Attitude Questionnaire（ ITAQ） at the time of enrollment and 1 year later. The obtained data were statistically analyzed. Results： The readmission rate and BPRC score of the family intervention were lower than the control group. And the subjective support,support utilization and ITAQ scores of were higher than that of control group（ P〈0. 05）. There was no significant difference in objective support（ P〉0. 05）. Conclusion：Compared with simple drug maintenance therapy,drug maintenance therapy combined with family intervention can effectively reduce patients readmission rates,maintain the patients in stable condition,promote the recovery of insight and improve subjective support and support utilization.