激素替代疗法对更年期综合征患者生活质量的影响

目的探讨激素替代疗法（HRT）对更年期综合征患者生活质量的影响。方法选择2013年1-11月在新乡市长垣县人民医院就诊的更年期综合征女性患者100例,随机分为研究组和对照组,各50例,2组患者均进行常规的健康宣教,研究组在此基础上给予HRT治疗。3个周期后,观察2组患者性激素的变化情况,同时采用更年期症状评分量表（Kupperman）、焦虑自评量表（SAS）、抑郁自评量表（SDS）及更年期生存质量量表（MENQOL）评价其生活质量。结果治疗后研究组雌二醇（E2）升高,促卵泡激素（FSH）、黄体生成素（LH）降低,与治疗前比较差异有统计学意义（P〈0.01）;治疗后研究组的E2高于对照组（P〈0.01）,而FSH,LH明显低于对照组（P〈0.01）。治疗后研究组的Kupperman,SAS,SDS及MENQOL评分与治疗前相比明显下降（P〈0.01）,且治疗后研究组生活质量的改善好于对照组（P〈0.01）。结论 HRT能显著改善更年期妇女的性激素水平,提高其生活质量,值得临床应用推广。

Impact of Hormone Replacement Therapy on Quality of Life in Patients with Menopausal Syndrome

Objective To investigate the impact of hormone replacement therapy （HRT） on quality of life in patients with menopausal syndrome. Method 100 cases of women patients with menopausal syndrome received in Changyuan People＇s Hospital from January to November 2013 were randomly divided into the study group and the control group, 50 cases in each group. Patients in both groups were given conventional health education and the study group also had HRT treatment. After three cycles, all the patients were observed the change of their sex hormones and their quality of life was evaluated with Menopausal Symptoms Rating Scale （Kupperman）, Self-Rating Anxiety Scale （SAS）, Self-Rating Depression Scale （SDS） and Menopause Quality of Life Scale （MENQOL）. Results After the treatment, the level of estradiol （E2 ） increased, follicle-stimulating hormone （FSH） and luteinizing hormone （LH） decreased in the study group; the difference between before and after treatment was statistically significant （P〈0.01） ; in the study group, the level of E2 was higher than the control group （P〈0.01）, but the levels of FSH and LH were significantly lower than the control group （P〈0.01）. Scores of Kupperman, SAS, SDS and MENQOL significantly decreased after the treatment in the study group （P〈0.01） and the improvement of quality of life in the study group after treatment was better than that of the control group（P〈0.01）. Conclusion HRT can significantly increase the levels of sex hormones in menopausal women and improve their quality of life, worthy of clinical application and further promotion.