美托洛尔与硝苯地平在大鼠体内药动学的相互影响

 目的 探讨美托洛尔对硝苯地平在大鼠体内药动学的相互影响。方法 12只大鼠随机分为两组，单独给药组灌胃给予硝苯地平，联合给药组灌胃给予硝苯地平与美托洛尔，分别应用HPLC法测定两组大鼠血浆中硝苯地平的血药浓度，用DAS2.0程序软件拟合药动学参数。结果 单独给药组和联合给药组的主要药动学参数：Cmax分别为（1291.69±248.26）和（1447.03±362.53） ng/ml，AUC_0-t：（1883.70±68.17）和（1635.56±376.80）（ng·h）/ml，Vd/F：（34.1±10.52）和（35.55±8.79）L/kg， t_1/2：（2.13±0.47）和（2.36±0.75）。两组间AUC_0-t的差异具有统计学意义（P＜0.05）。结论 美托洛尔对硝苯地平在大鼠体内的药动学过程的影响不明显。

Effect of metoprolol on pharmacokinetics of nifedipine in rats

Objective To study the effect of metoprolol on the pharmacokinetics of nifedipine in rats.Methods Twelve rats were randomly divided into two equal groups：A and B.Rats of group A were given nifedipine.Rats of group B were given nifedipine and metoprlol.Blood samples were taken from the animals for the determination of the plasma concentration of nifedipine by HPLC.Results The main pharmacokinetic parameters in the two groups were as follows： Cmax：（1291.69±248.26）and（1447.03±362.53）ng/ml,AUC0-t：（1883.70±68.17）and（1635.56±376.80）（ng·h）/ml,Vd/F：（34.19±10.52）and（35.5±8.79）L/kg,t1/2：（2.13±0.47）and（2.36±0.75）.The pharmacokinetic parameters of AUC0-t showed significant difference between the two groups（P〈0.05）.Conclusions The metoprolol has little effect on the pharmacokinetics of nifedipine in rats.