烟酸对poloxamer 407诱导的昆明小鼠血脂的影响

【目的】研究烟酸对poloxamer 407(P407)诱导的昆明小鼠高血脂动物模型血脂的影响。【方法】昆明小鼠给予烟酸(0.5或1 g/kg)灌胃,连续3 d,末次给药1 h后,给予动物腹腔注射P407 0.3 g/kg,于注射后的4、24、48 h取血测定甘油三酯和胆固醇含量,注射P407后24 h的血样同时测定高密度脂蛋白-胆固醇的含量。【结果】在造模前给予烟酸处理,能明显降低高血脂动物的血清甘油三酯和胆固醇水平,且剂量关系明显,此作用可维持至造模后的48 h。高血脂造模后的24 h,烟酸能明显升高模型动物的血清高密度脂蛋白-胆固醇水平。【结论】烟酸对于P407诱导的高血脂昆明小鼠模型具有降脂作用。

Hypolipidemic effects of nicotinic acid in poloxamer 407-induced hyperlipidemic Kunming mice model

【Objective】 To investigate the effects of nicotinic acid in poloxamer 407-induced hyperlipidemic Kunming mice model.【Methods】 Before a bolus of poloxamer 407（0.3 g/kg） was intraperitoneally dosed,Kunming mice were pretreated orally with nicotinic acid（0.5 or 1g/kg） for 3 days.Blood triacylglycerol（TG） and cholesterol（CHO） were measured at 0,4,24 and 48 h after the poloxamer 407 injection,and the blood HDL-CHO level of Time24h were measured.【Results】 Poloxamer407 injection caused hyperlipidemia in Kunming mice.Nicotinic acid decreased dose-dependently the blood TG and CHO,and this hypolipidemic effect lasted up to 48 h after injection.Moreover,nicotinic acid increased blood HDL-CHO in poloxamer 407-induced hyperlipidemic mice.【Conclusion】 Nicotinic acid has a hypolipidemic effects in poloxamer 407-induced hyperlipidemic Kunming mice model.