无抽搐电痉挛治疗精神障碍患者严重药物反应的临床研究

目的探讨无抽搐电痉挛治疗严重药物反应的疗效及安全性。方法采用入院顺序分层随机法,将84例严重药物反应患者分为研究组和对照组,采用自制量表观察疗效,共观察6d,在治疗前及治疗第2d、第4d、第6d评定疗效。结果治疗第2d,研究组自制量表总分较治疗前有显著改善(P<0.05),而对照组无显著性改善。治疗第6d,研究组和对照组的量表总分及各因子分较治疗前均有显著性变化(P<0.05),与对照组相比,研究组量表总分及各因子分均有显著性差异(P<0.05)。研究组未出现严重不良反应。结论无抽搐电痉挛治疗某些严重药物反应快速、有效、安全,值得临床试用。

A comparative study of modified electroconvulsive therapy in the treatment of withdrawal reaction

Objective To explore the efficacy of modified electroconv-ulsive therapy(MECT) in the treatment of withdrawal reaction.Methods A total of 84 patients with withdrawal reaction were randomly divided into study group with MECT and contort group for heteropathy of 6days.They were assessed and analysed contrastively using self-made scale.Results In the second day,the total and factor scores of scales in the study group were significantly lower than before treatment(P<0.05) and there was no difference in the control group(P>0.05).In the sixth day,there were significant improvement in the study group and control group(P<0.05).The total and factors scores of scales had significant differences between study group and control group(P<0.05).Conclusion MECT is effective for treating patients with withdrawal reaction.No severe side effects was found in study group.