孕激素治疗前后子宫内膜微血管密度和血管内皮生长因子表达的变化

【目的】探讨应用孕激素治疗前后子宫内膜微血管密度(microvessel density,MVD)及血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的变化,了解VEGF及MVD在围绝经期无排卵型功能失调性子宫出血(功血)发病过程中的作用。【方法】选择患者为病例组,月经稀发者为对照组,对子宫内膜进行病理学检查,采用免疫组化法进行MVD计数和VEGF检测。【结果】用药前病例组子宫内膜中MVD、VEGF的表达较用药后显著升高,且与对照组相比明显升高。【结论】无排卵性功血患者的异常出血与子宫内膜中MVD、VEGF表达失衡引起子宫内膜微环境的改变有关。

Expressions of microvessel density, vascular endothelial growth factor in endometrium before and after taking norethisterone

Objective] To compare the expressions of microvessel density （MVD）, vascular endothelial growth factor （VEGF） in endometrium before and after taking norethisterone. Investigate the effect of MVD and VEGF on peri-menopausal period anovulatory dysfunctional uterine bleeding. Method ] Select the patient as case group, menstrual volume diminished as control group. We test the expression of MVD and VEGF by immunohistochemistry. Result] The expression of MVD and VEGF in case group is higher than controls before taking norethisterone significantly. But after taking norethisterone it was just same as that of the control. Conclusion ] Over-expressions of MVD and VEGF in endometrium, which result in angiogenesis and abundant blood vessel net ,are related to abnormal uterine bleeding in simple hyperplasia. Progesterone can down regulate expression of the MVD and VEGF in the endometrium with simple hyperplasia.