帕罗西汀联合心理治疗对结直肠癌患者焦虑抑郁的疗效观察

目的探讨帕罗西汀辅以心理治疗对结直肠癌患者焦虑及抑郁的疗效。方法采用汉密尔顿抑郁量表（HamiltonDepression Scale,HAMD-24）和汉密尔顿焦虑量表（Hamilton Anxiety Scale,HAMA）对2009年6月-2011年6月住院的200例结直肠癌患者进行评分,调查结直肠癌患者中抑郁焦虑的发生情况。将最终伴抑郁或（和）焦虑的153例患者随机分为对照组、帕罗西汀组、心理治疗组以及帕罗西汀＋心理治疗组,以HAMD-24和HAMA评分作为疗效评价指标。结果与非肿瘤住院患者相比,结直肠癌患者中抑郁焦虑的发生率较高（P〈0.05）,治疗后帕罗西汀组、心理治疗组HAMD-24、HAMA评分比对照组下降更为显著（P〈0.05）,心理治疗组较帕罗西汀组疗效明显（P〈0.05）,联合干预组较单独采用帕罗西汀或心理治疗评分下降最为显著（P〈0.05）。结论帕罗西汀辅以心理治疗对结直肠癌患者围手术其抗焦虑抑郁效果显著,可提高患者生活质量。

Curative effect observation of paroxetine combined with psychotherapy treated on colorectal cancer patients with depression and anxiety

Objective To study the efficacy of paroxetine and psychotherapy with depression and anxiety in colon cancer patients.Methods 200 patients who were scheduled for surgery were investigated by using Hamilton Depression Scale(HAMD-24) and Hamilton Anxiety Scale(HAMA),153 patients which HAMD-24 scale over 20 and HAMA scale over 14,were randomly divided into four groups: control group,paroxetine group,psychotherapy group and combination therapy group.Results The comorbidity rate of depression and anxiety in colon caner patients were higher than non-tumor patients(P <0.05),the scale of HAMD-24 and HAMA in therapy group(paroxetine,psychotherapy and combination therapy) after treatment was lower than that of before(P <0.05),The scale of combination group was significantly lower than paroxetine group and psychotherapy group(P <0.05).Conclusion Psychotherapy combined with paroxetine can efficiently improve the depression and anxiety in colon cancer patients.