强酸性阳离子交换树脂催化合成乙酰水杨酸的研究

目的:探讨001×7强酸性阳离子交换树脂催化合成乙酰水杨酸的方法和最佳工艺。方法:通过正交试验探讨了乙酸酐与水杨酸的摩尔比、反应时间、催化剂用量和反应温度对乙酰水杨酸产率的影响,并探讨催化剂的催化能力与使用次数的关系。结果:乙酸酐与水杨酸的摩尔比为3∶1、催化剂用量为水杨酸质量的14.50%、反应时间120 min、反应温度60℃时,乙酰水杨酸产率最高,为77.93%。结论:001×7强酸性苯乙烯系阳离子交换树脂对酯化反应催化效果好,副反应少,对环境污染小,能重复使用,值得大力推广。

Synthesis of acetylsalicylic acid using strong-acidic cation-exchange resin as catalyst

Objective:To optimize the technology of synthesizing acetylsalicylic acid using 001×7 strong-acidic cation-exchange resin as catalyst.Methods:Orthogonal experiment was performed to examine the effect of molar ratio of reactants,reaction time,dosage of catalyst,and reaction temperature on the yield of product as well as the efficiency and frequencies of the resin recycled and shifted on the synthesis.Results:The optimal reaction conditions were 3∶1(the ratio of acetic anhydride to salicylic acid,n:n),in a dosage of the resin 14.50% of salicylic acid,for the reaction time of 120 min at temperature of 60 ℃,which led to a yield of 77.93%.Conclusion:001×7 strong-acidic cation-exchange resin works well on esterification reaction as a environmentally friendly catalyst and is worthy of wider use,for it has efficient activity,less adverse reaction and recyclable advantages.