Micro-computed tomography for evaluating alveolar bone resorption induced by hyperocclusion |
| |
| Authors: | Takashi Tsutsumi Hiroshi Kajiya Takashi Tsuzuki Kazuko T. Goto Koji Okabe Yutaka Takahashi |
| |
| Affiliation: | 1. Department of Oral Rehabilitation, Fukuoka Dental College, Fukuoka, Japan;2. Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Fukuoka, Japan;3. Department of Dental Hygiene, Fukuoka College of Health Sciences, Fukuoka, Japan |
| |
| Abstract: | PurposeOcclusal trauma, resulting in the destruction of alveolar bone, is a form of periodontal disease caused by excessive mechanical stress (MS) during hyperocclusion. Previously, we showed that C MethodsUnder anesthesia, a stainless steel wire was attached to the molars of 5-week-old C57/BL6 wild-type (WT) mice, CCL2?/? mice, and CCR2?/?mice to induce occlusal force overload. At days 0 and 7, hard tissue samples were harvested and analyzed by micro-computed tomography.ResultsIn the WT mice, bone mineral density of the alveolar bone was significantly decreased at day 7 as compared with day 0, with marked alveolar bone resorption observed. Similarly, significant alveolar bone resorption was observed in the CCL2?/? and CCR2?/? mice at day 7 as compared with day 0.ConclusionsMicro-computed tomographic images can be used to measure changes in bone mineral density in a mouse model of hyperocclusion. This method may be useful for further investigating bone changes in other periodontal disease research fields. |
| |
| Keywords: | Alveolar bone Micro-CT Occlusal traumatism Periodontal disease Periodontal tissues |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
