The impact of postoperative complications on health-related quality of life in older patients with rectal cancer; a prospective cohort study |
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Authors: | Alice M Couwenberg Fleur SA de Beer Martijn PW Intven Johannes PM Burbach Anke B Smits Esther CJ Consten Anandi HW Schiphorst Niels AT Wijffels Marnix AJ de Roos Marije E Hamaker Wilhemina MU van Grevenstein Helena M Verkooijen |
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Institution: | 1. Department of Radiation-Oncology, University Medical Center Utrecht, Utrecht, The Netherlands;2. Department of Surgery, Meander Medisch Centrum, Amersfoort, The Netherlands;3. Department of Surgery, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands;4. Department of Surgery, Diakonessenhuis, Utrecht, The Netherlands;5. Department of Surgery, Zuwe Hofpoort Ziekenhuis, Woerden, The Netherlands;6. Department of Surgery, Ziekenhuis Rivierenland, Tiel, The Netherlands;7. Department of Geriatric Medicine, Diakonessenhuis, Utrecht, The Netherlands;8. Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands;9. Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands |
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Abstract: | ObjectivesAs result of the aging population and increasing rectal cancer incidence, more older patients undergo treatment for rectal cancer. This study compares treatment course, postoperative complications, and quality of life (QOL) between older and younger patients with rectal cancer and evaluates the impact of postoperative complications on QOL in the elderly.Materials and MethodsPatients with rectal cancer participating in a prospective colorectal cancer cohort and referred for radiotherapy between 2013 and 2016 were included. QOL was assessed with the cancer questionnaire of the European Organisation for Research and Treatment of Cancer (EORTC QLQ-C30) before treatment and at three, six, and twelve months. Outcomes were compared between older patients (≥ 70 years) and younger patients (< 70 years) and stratified by presence of postoperative complications.ResultsIn total, 115 (33%) older patients and 230 (67%) younger patients were included. Compared to younger patients, older patients underwent significantly more often short-course radiation with delayed surgery (6.1% and 19.1% respectively) and less often chemoradiation (62.6% and 39.1% respectively), and were more likely to undergo a Hartmann procedure with permanent stoma (3.5% and 13.0% respectively) instead of sphincter-sparing surgery (43.9% and 29.6% respectively). Postoperative complication rates were similar (38.5% in older patients versus 34.7% in younger patients). Older patients had worse physical functioning at six and twelve months after diagnosis compared to younger patients. Presence of postoperative complications had a significant stronger impact on physical- and role functioning in older patients.ConclusionOlder patients undergo more often a tailored treatment approach for rectal cancer than younger patients. With this tailored approach, similar postoperative complication rates and QOL are achieved. However, postoperative complications have a larger negative impact on physical- and role functioning in older patients which indicates a need for better prediction of postoperative complications in the elderly. |
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Keywords: | Elderly Rectal cancer Neoadjuvant therapy Surgery Postoperative complications Quality of life Functioning |
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