布托啡诺对全麻术后躁动的防治作用

目的评价布托啡诺用于预防和治疗全麻患者术后躁动的有效性与安全性。方法ASAⅠ～Ⅱ级上腹部择期手术患者40例,随机分为对照(C)组与布托啡诺(B)组,每组20例。在术毕停用麻醉药即刻,C组经静脉注射生理盐水2ml;B组静脉注射布托啡诺0.02mg/kg。记录停用麻醉药前、拔管即刻、拔管后5min时的心率、血压,并对循环稳定程度、躁动程度、镇静状态进行评分。结果与麻醉前相比,拔管时、拔管后5min对照组患者血压明显升高(P<0.05)、心率加快(P<0.05),而布托啡诺组血压、心率相对平稳,两组比较有显著性差异(P<0.05)。与C组比较布托啡诺组躁动发生率更低(P<0.05),患者安静(P<0.05)。C组有6例患者术后持续躁动,经静脉注射布托啡诺0.02mg/kg,症状控制率达83.33%。结论布托啡诺是全麻术后躁动预防与治疗理想的选择药物。

Butorphano in the prevention & treatment of emergence agitation after general anaesthesia

Objective To evaluate the prophylaxis and treatment effects of butorphano on the emergence agitation after general anasethesia operation. Method The 40 patients subjected to epigast surgery were divided into two groups (20 patients in each group) randomly: butorphanol group, control group. When stopped anaesthetic use in the ending operation butorphanol group received immediately intravenous injection of butorphanol 0.02mg/kg, control group intravenous injection of physiological saline 2ml. Result Compared with the anaesthesia before, after cupping, the cupping the 5 min, in control group patients' SBP had obvious ascension (P <0.05), the heart rate speeded up (P <0.05); But in butorphanol group SBP, the heart rate was all steady, between two groups there had the significant difference (P<0.05); compared to control group, emergence agitation formation rate of butorphanol group was lower (P <0.05), the patients were silence. The six patients in control group emerge unremitting agitation, viaintravenous injection of butorphano 0.02mg/kg, their symptom relief rate was up to 83.33%. Conclusion Butorphano is an ideal drug for prophylaxis and treatment of the emergence agitation after general anaesthesia.