溃疡性结肠炎患者P-选择素检测和血小板计数的临床意义

目的:探讨溃疡性结肠炎(ulcerative colitis,UC)和血小板计数及血小板活化状态的关系.方法:对54例活动期溃疡性结肠炎、26例缓解期溃疡性结肠炎和正常对照组30例采用血细胞记数仪测定血小板数量.流式细胞术检测P-选择素(CD62p).结果:①血小板计数:活动期UC患者血小板计数(212.2±97.6)×109/L]明显高于缓解期(168.7±67.8)×109/L]和对照组(166.8±81.4)×109/L](P<0.01);缓解期患者与对照组相比无明显差异(P>0.05).②P-选择素水平:与对照组(3.9±1.2%)和缓解期(8.6±2.1%)患者组比较,活动期溃疡性结肠炎患者P-选择素(13.3±3.4)%显著升高(P<0.01),缓解期患者P.选择素仍高于正常对照组(P<0.05).③在活动期UC患者中,对于不同的病情程度,血小板计数与P-选择素水平有显著性差异.结论:活动期溃疡性结肠炎体内存在血小板活化;p-选择素和血小板计数的变化对评价病情活动性与严重程度均有良好的价值.

Clinical significance of P-selectin and Platelet Count in patients with ulcerative colitis

Objective:To study the correlation between platelet activation status and ulcerative colitis(UC). Methods:P-selectin(CD62p) was determined with flow cytometry,and Platelet Count was tested by automatic blood cell counter including 54 UC patients in active stage,26 UC patients in remittent stage and 30 healthy controls. Results:The Platelet Count of the active UC group was (212.2 ± 97.6) × l09/L,significantly higher than those of the remittent UC group and the control group(168.7 ± 67.8) × l09/L and(166.8 ± 81.4) × l09/L,both P < 0.01). However,there was no significant difference between the remittent UC group and the control group(P > 0.05). The P-selectin(CD62p) of the active UC and the remittent UC groups were(13.3±3.4)% and (8.6±2.1)%. Both significantly higher than that of the control group (3.9 ± 1.2)%; both P < 0.01] and there also was a significant difference between the active and remittent groups(P < 0.01). In the active UC group,the more severe the state of illness,the higher levels of the Platelet Count and the P-selectin. Conclusion:Increased platelet activation is involved in active ulcerative colitis. P-selectin(CD62p) and Platelet Count may be of great value in judging the activity state and the severity of UC.