| DEPLETION OF O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND POTENTIATION OF 1-(4-AMINO-2-METHYL-5- PYRIMIDINYL) METHYL-3 (2-CHLOROETHYL)-3-NITRO- SOUREA ANTITUMOR EFFECT BY STREPTOZOTOCIN |
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| 引用本文： | 陈建敏,章扬培,隋建丽,陈月能. DEPLETION OF O~6-METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY AND POTENTIATION OF 1-(4-AMINO-2-METHYL-5- PYRIMIDINYL) METHYL-3 (2-CHLOROETHYL)-3-NITRO- SOUREA ANTITUMOR EFFECT BY STREPTOZOTOCIN[J]. 中国癌症研究, 1993, 5(1): 48-52. DOI: 10.1007/BF02997493 |
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| 作者姓名： | 陈建敏 章扬培 隋建丽 陈月能 |
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| 作者单位： | Department of Biochemistry，Institute of Radiation Medicine，Beijing 100850，Department of Biochemistry，Institute of Radiation Medicine，Beijing 100850，Department of Biochemistry，Institute of Radiation Medicine，Beijing 100850，Department of Biochemistry，Institute of Radiation Medicine，Beijing 100850 |
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| 摘 要： | O6-methylguanine-DNA Methyltransferase (MGMT) can specifically repair the DNA demage Induced by chioroethylnitrosoureas (CENU) such at 1-(4-amino-2-methyt-pyrlmidinyl) methyl-3-(2-chloroethyl-)-3-nitrosourea (ACNU), constituting the molecular basis of tumor cell resistance to CENU. The present study demonstrated that sensitization of resistant tumor cells to ACNU could be achieved by streptozotocin (STZ) treatment which could deplete MGMT activity in vitro and in vivo. It suggested that depletion of the molecular basis of tumor cell resistance to chemotherapeutic agents might be a practicable way to improve the effectiveness of tumor chemotherapy.
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Depletion of O6-methylguanine-DNA methyltransferase activity and potentiation of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitro-sourea antitumor effect by streptozotocin |
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| Jianmin Chen,Yangpei Zhang,Jianli Sui,Yueneng Chen. Depletion of O6-methylguanine-DNA methyltransferase activity and potentiation of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitro-sourea antitumor effect by streptozotocin[J]. Chinese Journal of Cancer Research, 1993, 5(1): 48-52. DOI: 10.1007/BF02997493 |
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| Authors: | Jianmin Chen Yangpei Zhang Jianli Sui Yueneng Chen |
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| Affiliation: | 1. Department of Biochemistry, Institute of Radiation Medicine, 100850, Beijing
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| Abstract: | O6-methylguanine-DNA Methyltransferase (MGMT) can specifically repair the DNA demage Induced by chioroethylnitrosoureas (CENU) such at 1-(4-amino-2-methyt-pyrlmidinyl) methyl-3-(2-chloroethyl-)-3-nitrosourea (ACNU), constituting the molecular basis of tumor cell resistance to CENU. The present study demonstrated that sensitization of resistant tumor cells to ACNU could be achieved by streptozotocin (STZ) treatment which could deplete MGMT activity in vitro and in vivo. It suggested that depletion of the molecular basis of tumor cell resistance to chemotherapeutic agents might be a practicable way to improve the effectiveness of tumor chemotherapy. |
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| Keywords: | Methyltransferase Streptozotodn ACNU Tumor cell line Drag resistance. |
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