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Functional and morphological effects of defibrotide on renal ischemia |
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| Authors: | M G Comandella P Rigotti M Valente G Pittoni N Baldan E Ganz P Amodio E Ancona |
| Institution: | 1. Istituto di Semeiotica Chirurgica, University of Padua, Via Facciolati 71, I-35127, Padova, Italy 3. Istituto di Anatomia Patologica, University of Padua, Via Facciolati 71, I-35127, Padova, Italy 4. Istituto di Anestesia a Rianimazione, University of Padua, Via Facciolati 71, I-35127, Padova, Italy 5. Istituto di Clinica Medica II, University of Padua, Via Facciolati 71, I-35127, Padova, Italy |
| Abstract: | Defibrotide (Df) has been reported to protect various organs from ischemic damage. The aim of this study was to evaluate the effect of Df on renal function and morphology after warm kidney ischemia. Divided into two groups, 14 pigs underwent bilateral renal clamping for 90 min. One group (7 pigs) was treated with Df (32 mg/kg per h) for 6 h, whereas the control group received 5000 IU of heparin. Serum levels of blood urea nitrogen (BUN) and creatinine measured for 6 days were significantly higher in the control group (peak 26.8±16.7 vs 11.0±2.9 mmol/l and 501.2±351.4 vs 230.2±68.0 μmol/lP<0.05). Renal biopsy evidenced a lesser extent of tubular and endothelial damage in Df-treated animals. In conclusion, Df provided relevant protection against renal ischemic injury. |
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