米非司酮对早孕妇女血清一氧化氮和子宫局部血流的影响

探讨米非司酮对早孕妇女血清一氧化氮及子宫局部血流的影响。方法 利用镀铜镉还原法测定服用米非司酮前,后的早孕妇女及正常非孕妇女血清ＮＯ浓度,同时利用彩色多普勒超声显像监测子宫局部血流变化,并观察流产后绒毛和蜕膜组织的超微结构。结果早孕妇女血清ＮＯ浓度明显高于正常非孕妇女,服米非司酮后血清ＮＯ浓度明显低于服药前;服米非司酮后子宫动脉和滋养层动脉血流的指数,收缩期血流峰值与舒张期血流最小值的比值,较服药

Effects of mifepristone on the serum nitric oxide level and uterine blood flow in early pregnant women

Objective To study the effects of mifepristone on serum nitric oxide (NO) level and uterine blood flow in early pregnant women. Methods Serum NO concentrations of 58 early pregnant women and 15 normal nonpregnant women were measured by a copper coated cadmium reduction method, and uterine artery and trophoblastic blood flow were determined by color doppler flow imaging (CDFI). The ultrastructure of villi and decidua were studied under electron microscopy. Results Compared with nonpregnant women, serum NO concentration was significantly higher in early pregnant women( P <0.01). After administration of mifepristone, serum NO level was significantly decreased, resistance index(RI) and systolic to diastolic ratio(S/D) ratio of uterine artery and trophoblastic blood flow were significantly higher than that of normal early pregnancy( P <0.05).Conclusion Mifepristone may exert effects on uterine blood flow by decreasing serum NO level.