卡介菌多糖核酸对变应性鼻炎的免疫调节及临床疗效观察

目的:观察卡介菌多糖核酸(BCG-PSN)对常年性变应性鼻炎患者的免疫调节作用及临床疗效。方法:将60例常年性变应性鼻炎患者随机分为试验组和对照组,每组30例。试验组在与对照组相同治疗的基础上给予卡介菌多糖核酸注射液1ml(0.5mg),肌肉注射,隔日1次,疗程为6周。两组均随访3个月,每2周门诊随访1次,对临床情况进行评价,并检测两组患者治疗前、后血清IgA、IgG、IgM、IgE、CD3、CD4及CD8水平。结果:试验组有效率为93.33%,对照组为63.33%,其差异有统计学意义(P<0.05);卡介菌多糖核酸治疗后CD3、CD4、CD4/CD8水平均明显升高,分别与治疗前及对照组的治疗后比较,差异有统计学意义(均P<0.05)。治疗后IgA、IgM和IgE明显降低,与治疗前比较,差异均有统计学意义(均P<0.05),其中IgE与对照组的治疗后比较,差异亦有统计学意义(P<0.05)。结论:卡介菌多糖核酸可调节常年性变应性鼻炎患者的免疫功能,与抗过敏药物联合应用可提高其疗效,具有临床实用价值。

Immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid on perennial allergic rhinitis

OBJECTIVE: To observe the immune modulatory and therapeutic effect of BCG polysaccharides nucleic acid (BCG-PSN) on patients with perennial allergic rhinitis. METHOD: Sixty patients with perennial allergic rhinitis were randomly divided into two groups, 30 in the test group were treated with BCG-PSN plus ketotefen and 30 in the control group were treated with ketotefen respectively. All patients were followed up and assessed for 3 months, and the blood samples were collected before treatment and 3 months after treatment for measuring the blood IgA, IgG, IgM, IgE, CD3, CD4 and CD8. RESULT: In the test group, the total effective rate was significantly higher comparable to that in the control group. After treatment of BCG-PSN, blood CD3, CD4 and CD4/CD8 were significantly increased. IgE significantly reduced (P < 0.05). CONCLUSION: BCG polysaccharides nucleic acid can modulate the cellular immunofunction of patients with perennial allergic rhinitis and can increase the curative rate on perennial allergic rhinitis.