| 急性胰腺炎腺泡细胞损伤机制的研究进展 |
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| 引用本文： | 吴丽,蔡宝昌.急性胰腺炎腺泡细胞损伤机制的研究进展[J].世界华人消化杂志,2012(15):1307-1311. |
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| 作者姓名： | 吴丽 蔡宝昌 |
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| 作者单位： | 南京中医药大学药学院 |
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| 基金项目： | 国家自然科学基金资助项目,No.81073022;江苏省中医药局科技基金资助项目,No.LZ11190;南京中医药大学中药学一级学科开放课题基金资助项目,No.2011ZYX4-006~~ |
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| 摘 要： | 急性胰腺炎(acute pancreatitis,AP)是临床常见急腹症,发病机制复杂,其中,胰腺腺泡细胞损伤、胰酶提前激活导致胰腺自身消化是胰腺炎的始发因素.因此,探讨腺泡细胞损伤机制对阐明AP发病机制具有重要意义.近年来研究认为,钙超载、内质网应激、线粒体损伤与胰腺腺泡细胞损伤关系密切,本文就其研究进展作一综述.
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| 关 键 词： | 胰腺腺泡细胞 钙超载 内质网应激 线粒体损伤 |
Advances in understanding the pathogenesis of acute pancreatitis-associated acinar cell injury |
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| Li Wu,Bao-Chang Cai.Advances in understanding the pathogenesis of acute pancreatitis-associated acinar cell injury[J].World Chinese Journal of Digestology,2012(15):1307-1311. |
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| Authors: | Li Wu Bao-Chang Cai |
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| Institution: | ,College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,Jiangsu Province,China |
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| Abstract: | Acute pancreatitis is a common severe disease involving a complicated cascade of events.The injury of pancreatic acinar cells is the trigger of local and systemic inflammation.Calcium overload,endoplasmic reticulum stress,mitochondrial injury are closely associated with the injury of pancreatic acinar cells.This review aims to elucidate the pathogenesis of acute pancreatitisassociated acinar cell injury. |
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| Keywords: | Pancreatic acinar cell Calcium overload Endoplasmic reticulum stress Mitochondrial injury |
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