左卡尼汀治疗老年不稳定性心绞痛患者疗效研究

目的观察左卡尼汀（L-CN）治疗老年不稳定性心绞痛患者的临床疗效。方法将200例老年冠心病患者随机分为两组,每组100例。对照组给予常规治疗,治疗组在常规治疗基础上加用左卡尼汀每日2.0g静点,疗程7d,观察两组治疗前、后心绞痛发作次数、持续时间、硝酸甘油用量、心绞痛改善总有效率及治疗前后心电图改善情况。结果两组患者心绞痛发作频率、持续时间、硝酸甘油用量比较,差异均有统计学意义（P〈0.05）。心电图改善情况差异有统计学意义（P〈0.05）。治疗组和对照组临床症状改善总有效率分别为92%和82%,两组比较,差异有统计学意义（P〈0.05）。结论左卡尼汀治疗老年不稳定性心绞痛有效,疗效确切。

The effect of L-carnitine on the aged patients with unstable angina pectoris

【Objective】 To observe the effect of L-carnitine on the aged patients with unstable angina pectoris.【Methods】200 aged patients with unstable angina pectoris were randomLy devided into two groups,each group including 100 patients.The patients of the control group were applied routine treatment.The patients of treatment group were applied routine treatment and L-carnitine injection 2.0 gram combined with physiological salt solution by intravenous drip once a day,the course was 7 days.To observe the total effective rate of clinical symptom and the change of ST-T on ECG,the frequencies of angina,the time of breaking out angina pectoris and the demand of nitroglycerin tablets per week before and after treatment.【Resluts】The frequencies of angina,the angina time and the demand of nitroglycerin tablets of the two groups decreased obviously after treatment,All of them there were meaning of statistics(P <0.05).The change of ST-T on ECG of the treatment group was more obvious than the other group’s,there was meaning of statistics(P <0.05).The total effective rate of clinical symptom of the treatment group and the control group were 92% and 82%.There was meaning of statistics(P <0.05).【Conclusion】L-carnitine is effective and safe on the treatment of the patients with unstable angina pectoris.