利培酮和氟哌啶醇对精神分裂症白细胞介素的作用及其与疗效的关系

目的　探讨典型、非典型抗精神病药对精神分裂症白细胞介素 (IL)的影响及其与疗效之间的关系 ,以及免疫状态与精神症状的关系。方法　采用随机、双盲法应用固定剂量的利培酮和氟哌啶醇对 78例慢性精神分裂症进行 12周治疗 ,并在治疗前后评定PANSS量表。以 18例健康人为对照。同时在治疗前后测定血浆IL 2、IL -6和IL -8含量。结果①利培酮和氟哌啶醇治疗均降低精神分裂症过高的IL 2水平 ,两者之间无明显差异。②两种药物对患者过高的IL -6、IL 8水平均无明显影响。③治疗前IL 2、IL 8越低 ,则疗效越好。④治疗后IL 8水平与精神症状、主要是阳性症状有关。结论非典型和典型抗精神病药对精神分裂症免疫应答产生一定程度的抑制作用 ,两者之间无明显差异 ;患者治疗前的免疫水平与疗效之间存在一定的关系

The effect of risperidone and haloperidol treatment on plasma interleukin 2, 6, 8 in inpatients with schizophrenia and their relationship to outcome

Objective The purpose of the study was to explore the effect of atypical and typical antipsychotic medications on plasma interleukin 2, 6 and 8 and their relationship with outcome. Methods 78 chronic inpatients with schizophrenia were treated with a fixed dosage of risperidone or haloperidol for 12 weeks in a double blind randomized design. PANSS scale was rated before and after treatment. Plasma interleukin 2, interleukin 6 and interleukin 8 were measured at baseline and endpoint, as compared with 18 normal controls. Results 1. Either risperidone or haloperidol treatment reduced the enhanced IL 2 level with no significant difference; 2. The two medications did not produce significant influence on the elevated IL 6 and IL 8 levels. 3. Those patients with the lower baseline plasma IL 2and IL 8 levels had a better outcome. 4. There was significant positive correlation between IL 8 level at endpoint and psychotic symptom, especially positive symptom. Conclusions Typical and atypical antipsychotic medications may inhibit the immune response in schizophrenia to some extent, but there was no significant difference between them. There may be a relationship between the immune function at baseline and outcome. Additionally, a significant correlation may exist between IL 8 level and psychopathology, or between IL 2 level and outcome.