5-HT1A receptor function in depression: effect of chronic amitriptyline treatment |
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| Authors: | K P Lesch J Disselkamp-Tietze A Schmidtke |
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| Institution: | (1) Present address: Department of Psychiatry, University of Würzburg, Würzburg, Germany |
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| Abstract: | Summary Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment. |
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| Keywords: | 5-HT1A receptor hypothermia ipsapirone amitriptyline |
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