Amniotic fluid prolactin and fetal lung maturation |
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| Authors: | J W Johnson J E Tyson W Mitzner J C Beck B Andreassen W T London J Villar |
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| Affiliation: | 1. Division of Maternal and Fetal Medicine, Department of Gynecology and Obstetrics, University of Florida College of Medicine Gainesville, Florida, USA.;2. The Johns Hopkins University School of Medicine Baltimore, Maryland, USA.;3. the Infectious Disease Branch, National Institute of Neurological and Communicative Disorders and Stroke Bethesda, Maryland, USA.;1. Department of Medical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India;2. Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi 110029, India;1. Laboratory of Molecular and Functional Genetics, Faculty of Science, University of Sfax, Tunisia;2. Department of Pediatrics, Pediatric Emergency and Intensive Care, Hedi Chaker Hospital, Faculty of Medicine, Sfax, Tunisia;3. University of Jeddah, College of Science, Department of Biological Sciences, Saudi Arabia;4. University of Sfax, Higher Institute of Biotechnology, Unit of Plant Physiology and Functional Genomics, Sfax, Tunisia;5. LCBGM, Medical Biology and Pathology Department, APHP, HUEP, St Antoine Hospital, & Sorbonne University, 75012 Paris, France |
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| Abstract: | Concentrations of prolactin in amniotic fluid, fetal plasma, and maternal plasma were determined in 34 rhesus monkeys delivered by hysterotomy under general anesthesia at gestational ages of 110 to 160 days (term, 165 days). Included were 15 cases (gestational ages 110 to 143 days) in which the mothers received 2 mg of betamethasone intramuscularly daily for 3 days prior to delivery. Fetal lung maximum volumes were determined in addition to the following indices of fetal lung surfactant: lung alveolar stability, lung phosphatidylcholine concentrations, lung extract surface tensions, and amniotic fluid lecithin to sphingomyelin ratios. Amniotic fluid prolactin was found to correlate significantly with lung alveolar stability (r = 0.51; p less than 0.01), lung phosphatidylcholine (r = 0.51; p less than 0.01), lung extract surface tension (r = -0.39, p less than 0.05) and amniotic fluid lecithin/sphingomyelin ratio (r = 0.50; p less than 0.01). These correlations remained statistically significant even when the effects of gestational age were taken into account. These findings suggest that amniotic fluid may modulate fetal production of surfactant via its prolactin content. |
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