Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. |
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Authors: | B Dreno M Trossaert H L Boiteau P Litoux |
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Affiliation: | Department of Dermatology, H?tel Dieu, Nantes, France. |
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Abstract: | To explore the mechanism by which zinc acts on cutaneous inflammatory lesions, we studied granulocyte zinc levels and in vitro polymorphonuclear leukocyte chemotaxis in 20 acne patients before and after 2 months of zinc therapy (200 mg/day zinc gluconate). The zinc level was assayed by flame absorption spectrophotometry and chemotaxis was performed by agarose assay. After 2 months of treatment, a significant decrease in granulocyte zinc level associated with inhibition of chemotaxis (r = 0.69) was observed in 16 patients. This suggests that zinc anti-inflammatory action is related to inhibition of polymorphonuclear leukocyte chemotaxis induced by a decreased granulocyte zinc level. |
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