Department of Dermatology, Staffordshire Hospital Centre, Stoke-on-Trent ST4 7PA, UK;Department of Rheumatology North, Staffordshire Hospital Centre, Stoke-on-Trent ST4 7PA, UK
Abstract:
Hypersensitivity to topical hydrocortisone is becoming increasingly recognized. We present further evidence that this is mediated via a delayed-type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mononuclear cells of patients allergic to hydrocortisone. Protein binding of hydrocortisone or a degradation product may be important in the development of corticosteroid allergy.