异种移植的研究进展

目的总结异种移植的研究现状与进展。方法复习国内外关于异种移植研究的相关文献并进行综述。结果超急性异种排斥反应是异种移植面临的巨大问题，器官或组织的供体经过基因修饰后，在一定程度上可以减轻超急性异种排斥反应。由于不同的器官具有不同的特性，目前异种器官移植移植物的存活时间存在较大差异。结论通过对相关异种移植实验研究的分析，可以全面地了解异种移植的研究背景，为异种移植提供合适的研究方向。将经基因修饰的动物作为异种器官或组织的供体，有望使移植物避免或减轻超急性异种排斥反应。

Research Progress of Xenotransplantation

Objective To summarize the research progress of xenotransplantation. Methods Domestic and international publications about xenotransplantation were summarized and reviewed. Results Hyperacute xenograft rejection was a huge problem for xenotransplantation, but it could be alleviated if the organs or tissues of donor were genetically modified. So far the graft survival time differed greatly due to characteristics of different organ. Conclusions By reviewing the studies of relevant papers about xenotransplantation, a comprehensive understanding of research background and a suitable research direction of xenotransplantation can be supplied. The graft organs or tissues from genetically modified donors are expected to avoid or alleviate hyperacute xenograft rejection.