| Notch信号通路在消化系肿瘤中的研究进展△ |
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| 引用本文： | 盖大伟,郭凌云,刘涛,李玉民.Notch信号通路在消化系肿瘤中的研究进展△[J].普外基础与临床杂志,2013(10):1188-1192. |
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| 作者姓名： | 盖大伟 郭凌云 刘涛 李玉民 |
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| 作者单位： | [1]兰州大学第二医院普外科,甘肃兰州730030 [2]兰州大学第二医院甘肃省消化系肿瘤重点实验室,甘肃兰州730030 |
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| 基金项目： | △国家自然科学基金资助项目（项目编号：31270532）;兰州大学中央高校基本科研业务费专项基金（项目编号：lzujbky-2013-139） |
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| 摘 要： | 目的探讨Notch信号通路的结构特点、功能以及在消化系肿瘤中的研究进展。方法采用文献复习的方法，对研究Notch信号通路在消化系肿瘤分子机理的相关文献加以综述。结果Notch信号通路不仅在细胞正常发育、分化增殖和凋亡中起着重要的作用，而且与多种肿瘤的发生和发展具有相关性。结论对Notch信号通路进行合理的调控有可能为肿瘤的治疗开辟新的途径。
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| 关 键 词： | Notch信号通路 消化系肿瘤 上皮间质转化 |
Research Progress on Notch Signaling Pathway in Digestive Tumors |
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| Authors: | GAI Da-wei GUO Ling-yun LIU Tao LI Yu-min |
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| Institution: | 1. Departmeng of The Second Clinical Medical College of Lanzhou University, Lanzhou 730030, Gansu Province, China; 2. The Second Hospital of Lanzhou University, Key Laboratory of Digestive System Tumors, Lanzhou 730030, Gansu Province, China) |
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| Abstract: | Objective To investigate the structure characteristics, functions, and research progress of Notch signaling pathway in digestive tumors. Methods The related literatures about the molecular genetic mechanism of Notch signaling pathway were reviewed. Results The Notch signaling pathway plays an important role not only in normal cells＇ growth, differentiation, proliferation, and apoptosis but also in a variety of tumors＇ occurrence and development. Conclusion The reasonable regulation to Notch signaling pathway may open up new ways to the treatment of the tumor. |
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| Keywords: | Notch signaling pathway Digestive tumors Epithelial-mesenchymal transition |
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