缩胺硫脲类化合物的合成及其抗癌活性研究

合成了16个新型缩胺硫脲类化合物。先由硫酸二甲酯、水合肼与二硫化碳反应，生成肼基二硫代甲酸甲酯（Ⅱ），产率为60％。取代芳香酮、醛与Ⅱ反应，制备中间体Ⅲ，收率：51％－91％。Ⅲ与N－取代哌嗪反应制备目标代合物Ⅰ，收率：27．3％－85．7％。其结构经IR、^1H-NMR和元素分析等确证。体外抗癌活性测定表明，在适当的基代基匹配下，此类化合物有一定的抗癌活性。

A Study on Synthesis andAnticancer Activity of Thiosemicarbazones

Sixteen of thiosemicarbazones Ⅰ were synthesized.Hydrazine reacted with carbon disulfide and dimethyl sulfate in the presence of potassium hydroxide to form compound(Ⅱ) with the yield of 60%.Ⅱ reacted with ketone or aldehyde to form Ⅲ with the yield of 51%～91%.Ⅲ reacted with N-substitued piperazine to form Ⅰ with the yield of 27%～85%.Their structures of the compounds were comfirmed by IR,1H-NMR,elemental analysis,and the results showed that the thiosemicarbazone with proper substituents had somewhat activity.It is a valuable compound to be researched further.